Author | Ferro, Zaquer Suzana Munhoz Costa | |
Author | Souza, Bruno Solano de Freitas | |
Author | Leal, Marcos Maurício Tosta | |
Author | Kaneto, Carla Martins | |
Author | Azevedo, Carine Machado | |
Author | Silva, Igor Campos da | |
Author | Soares, Milena Botelho Pereira | |
Author | Santos, Ricardo Ribeiro dos | |
Author | DaCosta, Jaderson Costa | |
Access date | 2014-11-24T18:35:42Z | |
Available date | 2014-11-24T18:35:42Z | |
Document date | 2012 | |
Citation | COSTA-FERRO, Z. S. M. et al. Transplantation of bone marrow mononuclear cells decreases seizure incidence, mitigates neuronal loss and modulates pro-inflammatory cytokine production in epileptic rats. Neurobiology of Disease, v. 46, n.2, p. 302-313, 2012. | pt_BR |
ISSN | 1095-953X | |
URI | https://www.arca.fiocruz.br/handle/icict/8955 | |
Language | eng | pt_BR |
Publisher | Elsevier Inc | pt_BR |
Rights | open access | pt_BR |
Title | Transplantation of bone marrow mononuclear cells decreases seizure incidence, mitigates neuronal loss and modulates pro-inflammatory cytokine production in epileptic rats. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.nbd.2011.12.001 | |
Abstract | Approximately 30% of patients with mesial temporal lobe epilepsy do not respond to treatment with antiepileptic drugs. We have previously shown that transplantation of mononuclear bone marrow cells (BMC) has an anticonvulsant effect in acute epilepsy. Here, we used pilocarpine to induce epilepsy in rats and studied the effects of BMC injected intravenously either at the onset of seizures or after 10 months of recurrent seizures. BMC effectively decreased seizure frequency and duration. In addition, decreased levels of proinflammatory cytokines (TNF-α, IL-1ß and IL-6) and increased levels of anti-inflammatory cytokine (IL-10) were observed in the brain and serum of BMC-treated rats. Transplants performed at seizure-onset protected against pilocarpine-induced neuronal loss and gliosis and stimulated the proliferation of new neurons in epileptic rats. Our data demonstrate that BMC transplantation has potent therapeutic effects and could be a potential therapy for clinically intractable epilepsies | pt_BR |
Affilliation | Pontifícia Universidade Católica do Rio Grande do Sul. Instituto de Pesquisas Biomédicas e Instituto do Cérebro. Porto Alegre, RS, Brasil / Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Hospital São Rafael. Serviço de Anatomia Patológica e Citopatologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital São Rafael. Centro de Biotecnologia e Terapia Celular. Salvador, BA, Brasil | pt_BR |
Affilliation | Pontifícia Universidade Católica do Rio Grande do Sul. Instituto de Pesquisas Biomédicas e Instituto do Cérebro. Porto Alegre, RS, Brasil | pt_BR |
Subject | Temporal lobe epilepsy | pt_BR |
Subject | Bone marrow mononuclear cells | pt_BR |
Subject | Seizure frequency | pt_BR |
Subject | Neuronal loss | pt_BR |
Subject | Cytokines | pt_BR |
Subject | Pilocarpine | pt_BR |
DeCS | Transplante de Medula Óssea | pt_BR |
DeCS | Citocinas/biossíntese | pt_BR |
DeCS | Epilepsia/metabolismo | pt_BR |
DeCS | Leucócitos Mononucleares/transplante | pt_BR |
DeCS | Neurônios/metabolismo | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Transplante de Medula Óssea/métodos | pt_BR |
DeCS | Movimento Celular/fisiologia | pt_BR |
DeCS | Epilepsia/patologia | pt_BR |
DeCS | Incidência | pt_BR |
DeCS | Mediadores da Inflamação/metabolismo | pt_BR |
DeCS | Leucócitos Mononucleares/patologia | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos C57BL | pt_BR |
DeCS | Neurônios/patologia | pt_BR |
DeCS | Ratos | pt_BR |
DeCS | Ratos Wistar | pt_BR |