Author | Azevedo, Z.M. | pt_BR |
Author | Moore, Daniella Campelo Batalha Cox | pt_BR |
Author | Lima, F.C. | pt_BR |
Author | Cardoso, C.C. | pt_BR |
Author | Bougleux, R. | pt_BR |
Author | Matos, G.I. | pt_BR |
Author | Luz, R.A. | pt_BR |
Author | Xavier-Elsas, Pedro Paulo | pt_BR |
Author | Sampaio, E.P. | pt_BR |
Author | Gaspar-Elsas, M.I. | pt_BR |
Author | Moraes, M.O. | pt_BR |
Access date | 2014-11-14T10:54:07Z | |
Available date | 2014-11-14T10:54:07Z | |
Document date | 2012 | pt_BR |
Citation | AZEVEDO. Z.M. et al. Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: Importance in ARDS in septic pediatric critically ill patients. Hum. immunol., New York, v. 72, n. 6, p. 661-667, 2012. | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/8859 | |
Language | eng | pt_BR |
Publisher | Elsevier/North-Holland | pt_BR |
Rights | restricted access | pt_BR |
Title | Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: Importance in ARDS in septic pediatric critically ill patients | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.humimm.2012.03.007 | pt_BR |
Abstract | Accumulating evidence indicates that genetic background influences the outcome of sepsis, which
despite medical advances continues to be a major cause of morbidity and mortality. This study aimed
to evaluate the influence of SNPs LTA +252A > G, TNF-863C > A and TNF-308G > A on susceptibility to sepsis,
acute respiratory distress syndrome (ARDS), septic shock and sepsis mortality. A prospective casecontrol
study was carried out in a Brazilian pediatric intensive care unit and included 490 septic pediatric
patients submitted to mechanical ventilation and 610 healthy children. No SNP association was found
with respect to sepsis susceptibility. Nevertheless, a haplotype was identified that was protective against
sepsis (+252A/ 863A/ 308G; OR = 0.65; p = 0.03). We further observed protection against ARDS in
TNF-308 GA genotype carriers (OR = 0.29; p = 0.0006) and 308A allele carriers (OR = 0.40; p = 0.003).
In addition, increased risk for ARDS was detectable with the TNF-863 CA genotype (OR = 1.83; p = 0.01)
and the 863A carrier status (OR = 1.82; p = 0.01). After stratification according to age, this outcome
remained significantly associated with the 308GA genotype in infants. Finally, protection against
sepsis-associated mortality was found for the TNF-308 GA genotype (OR = 0.22; p = 0.04). Overall, our
findings document a protective effect of the TNF-308 GA genotype for the ARDS and sepsis mortality
outcomes, further providing evidence for an increased risk of ARDS associated with the TNF-863 CA
genotype. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Unidade de Terapia Intensiva Pediátrica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Unidade de Terapia Intensiva Pediátrica e Laboratório de Fisiopatologia Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Departamento de Pediatria. Unidade de Terapia Intensiva Pediátrica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Laboratório de Fisiopatologia Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Laboratório de Fisiopatologia Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Laboratório de Fisiopatologia Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Professor Paulo de Góes. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Laboratório de Fisiopatologia Humana. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Sepsis | pt_BR |
Subject | Children | pt_BR |
Subject | Tumor Necrosis Factor | pt_BR |
Subject | Lymphotoxin Alpha | pt_BR |
Subject | Acute Respiratory Distress Syndrome | pt_BR |
Subject | Genetic Polymorphism | pt_BR |
DeCS | Sepse | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Fatores de Necrose Tumoral | pt_BR |
DeCS | Linfotoxina-alfa | pt_BR |
DeCS | Síndrome do Desconforto Respiratório do Adulto | pt_BR |
DeCS | Polimorfismo Genético | pt_BR |