Author | Cardoso, Luciana Santos | |
Author | Rocha Barreto, Andréia de Souza | |
Author | Fernandes, Jamille Souza | |
Author | Oliveira, Ricardo Riccio | |
Author | Souza, Robson da Paixão de | |
Author | Carvalho Filho, Edgar Marcelino | |
Author | Araujo, Maria Ilma | |
Access date | 2014-11-10T19:21:44Z | |
Available date | 2014-11-10T19:21:44Z | |
Document date | 2013 | |
Citation | CARDOSO, L. S. et al. Impaired lymphocyte profile in schistosomiasis patients with periportal fibrosis. Clinical Developmental Immunology, p. 710647, 2013. | pt_BR |
ISSN | 1740-2530 | |
URI | https://www.arca.fiocruz.br/handle/icict/8782 | |
Language | eng | pt_BR |
Publisher | Hindawi Publishing Corporation | pt_BR |
Rights | open access | pt_BR |
Title | Impaired lymphocyte profile in schistosomiasis patients with periportal fibrosis. | pt_BR |
Type | Article | pt_BR |
DOI | dx.doi.org/10.1155/2013/710647 | |
Abstract | The Th2 immune response in chronic schistosomiasis is associated with the development of periportal fibrosis. However, little is known about the phenotype and activation status of T cells in the process. Objective. To evaluate the profile of T cells in schistosomiasis patients with periportal fibrosis. Methods. It was a cross-sectional study, conducted in the village of Agua Preta, Bahia, Brazil, which included 37 subjects with periportal fibrosis determined by ultrasound. Peripheral blood mononuclear cells were obtained by the Ficcol-hypaque gradient and the frequency of T cells expressing the surface markers CD28, CD69, CD25, and CTLA-4 was determined by flow cytometry. Results. The frequency of CD4(+)CD28(+) T lymphocytes was higher in individuals with moderate to severe fibrosis compared to patients with incipient fibrosis. We did not observe any significant difference in the frequency of CD4(+) T cells expressing CD69 among groups of individuals. There was also no significant difference in the frequency of CD8(+) T cells expressing CD28 or CD69 among the studied groups. Individuals with moderate to severe fibrosis presented a lower frequency of CD8(+) T cells, CD4(+)CD25(high) T cells, and CD4(+)CTLA-4(+) T cells when compared to patients without fibrosis or incipient fibrosis. The frequency of CD4(+)CD25(low) cells did not differ between groups. Conclusion. The high frequency of activated T cells coinciding with a low frequency of putative Treg cells may account for the development of periportal fibrosis in human schistosomiasis. | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia Departamento de Análises Clínicas e Toxicológicas. Salvador-BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. (INCT-DT/CNPq-MCT). Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. (INCT-DT/CNPq-MCT). Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador-BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. (INCT-DT/CNPq-MCT). Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador-BA, Brasil | pt_BR |
DeCS | Fibrose/etiologia | pt_BR |
DeCS | Subpopulações de Linfócitos/imunologia | pt_BR |
DeCS | Sistema Porta/patologia | pt_BR |
DeCS | Esquistossomose/complicações | pt_BR |
DeCS | Esquistossomose/complicações | pt_BR |
DeCS | Adolescente | pt_BR |
DeCS | Adulto | pt_BR |
DeCS | Idoso | pt_BR |
DeCS | Brasil | pt_BR |
DeCS | Linfócitos T CD4-Positivos/imunologia | pt_BR |
DeCS | Linfócitos T CD8-Positivos/metabolismo | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Estudos Transversais | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Ativação Linfocitária/imunologia | pt_BR |
DeCS | Subpopulações de Linfócitos/metabolismo | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Meia-Idade | pt_BR |
DeCS | Esquistossomose/diagnóstico | pt_BR |
DeCS | Adulto Jovem | pt_BR |