Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/8782
Title: Impaired lymphocyte profile in schistosomiasis patients with periportal fibrosis.
Authors: Cardoso, Luciana Santos
Rocha Barreto, Andréia de Souza
Fernandes, Jamille Souza
Oliveira, Ricardo Riccio
Souza, Robson da Paixão de
Carvalho Filho, Edgar Marcelino
Araujo, Maria Ilma
Affilliation: Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Farmácia Departamento de Análises Clínicas e Toxicológicas. Salvador-BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. (INCT-DT/CNPq-MCT). Brasil
Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. (INCT-DT/CNPq-MCT). Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador-BA, Brasil
Universidade Federal da Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. (INCT-DT/CNPq-MCT). Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador-BA, Brasil
Abstract: The Th2 immune response in chronic schistosomiasis is associated with the development of periportal fibrosis. However, little is known about the phenotype and activation status of T cells in the process. Objective. To evaluate the profile of T cells in schistosomiasis patients with periportal fibrosis. Methods. It was a cross-sectional study, conducted in the village of Agua Preta, Bahia, Brazil, which included 37 subjects with periportal fibrosis determined by ultrasound. Peripheral blood mononuclear cells were obtained by the Ficcol-hypaque gradient and the frequency of T cells expressing the surface markers CD28, CD69, CD25, and CTLA-4 was determined by flow cytometry. Results. The frequency of CD4(+)CD28(+) T lymphocytes was higher in individuals with moderate to severe fibrosis compared to patients with incipient fibrosis. We did not observe any significant difference in the frequency of CD4(+) T cells expressing CD69 among groups of individuals. There was also no significant difference in the frequency of CD8(+) T cells expressing CD28 or CD69 among the studied groups. Individuals with moderate to severe fibrosis presented a lower frequency of CD8(+) T cells, CD4(+)CD25(high) T cells, and CD4(+)CTLA-4(+) T cells when compared to patients without fibrosis or incipient fibrosis. The frequency of CD4(+)CD25(low) cells did not differ between groups. Conclusion. The high frequency of activated T cells coinciding with a low frequency of putative Treg cells may account for the development of periportal fibrosis in human schistosomiasis.
DeCS: Fibrose/etiologia
Subpopulações de Linfócitos/imunologia
Sistema Porta/patologia
Esquistossomose/complicações
Esquistossomose/complicações
Adolescente
Adulto
Idoso
Brasil
Linfócitos T CD4-Positivos/imunologia
Linfócitos T CD8-Positivos/metabolismo
Criança
Estudos Transversais
Feminino
Humanos
Ativação Linfocitária/imunologia
Subpopulações de Linfócitos/metabolismo
Masculino
Meia-Idade
Esquistossomose/diagnóstico
Adulto Jovem
Issue Date: 2013
Publisher: Hindawi Publishing Corporation
Citation: CARDOSO, L. S. et al. Impaired lymphocyte profile in schistosomiasis patients with periportal fibrosis. Clinical Developmental Immunology, p. 710647, 2013.
DOI: dx.doi.org/10.1155/2013/710647
ISSN: 1740-2530
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

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