Author | Barros, Taís Adelita de Almeida | |
Author | Freitas, Luiz Antonio Rodrigues de | |
Author | Filho, José M. B. | |
Author | Nunes, Xirley Pereira | |
Author | Harley, Ana Maria Giulietti | |
Author | Souza, Glória E. de | |
Author | Santos, Ricardo Ribeiro dos | |
Author | Soares, Milena Botelho Pereira | |
Author | Villarreal, Cristiane Flora | |
Access date | 2014-06-09T18:39:31Z | |
Available date | 2014-06-09T18:39:31Z | |
Document date | 2010 | |
Citation | BARROS, T. A. de A. et al. Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic pain. Journal of Pharmacy and Pharmacology, v. 62, p. 205–213, 2010. | pt_BR |
ISSN | 2042-7158 | |
ISSN | 10.1211/jpp/62.02.0008 | |
URI | https://www.arca.fiocruz.br/handle/icict/7807 | |
Language | eng | pt_BR |
Publisher | Royal Pharmaceutical Society of Great Britain | pt_BR |
Rights | open access | pt_BR |
Title | Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic pain. | pt_BR |
Type | Article | pt_BR |
Abstract | Objectives In the present study we investigated the antinociceptive, anti-inflammatory
and antipyretic effects of 7-hydroxycoumarin (7-HC) in animal models.
Methods The effects of oral 7-HC were tested against acetic acid-induced writhing,
formalin test, tail flick test, complete Freund’s adjuvant (CFA)-induced hypernociception,
carrageenan-induced paw oedema, lipopolysaccharide-induced fever and the rota rod test.
Key findings 7-HC (3–60 mg/kg) produced a dose-related antinociception against acetic
acid-induced writhing in mice and in the formalin test. In contrast, treatment with 7-HC
did not prevent thermal nociception in the tail flick test. A single treatment with 7-HC,
60 mg/kg, produced a long-lasting antinociceptive effect against CFA-induced hypernociception,
a chronic inflammatory pain stimulus. Notably, at 60 mg/kg per day over 4 days the
administration of 7-HC produced a continuous antinociceptive effect against CFA-induced
hypernociception. 7-HC (30–120 mg/kg) produced anti-inflammatory and antipyretic
effects against carrageenan-induced inflammation and lipopolysaccharide-induced fever,
respectively. Moreover, 7-HC was found to be safe with respect to ulcer induction. In the
rota rod test, 7-HC-treated mice did not show any motor performance alterations.
Conclusions The prolonged antinociceptive and anti-inflammatory effects of 7-HC, in
association with its low ulcerogenic activity, indicate that this molecule might be a good
candidate for development of new drugs for the control of chronic inflammatory pain and
fever. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / State University of Feira de Santana. Feira de Santana, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Paraíba. Paraíba, JP, Brasil | pt_BR |
Affilliation | Federal University of Paraíba. Paraíba, JP, Brasil | pt_BR |
Affilliation | State University of Feira de Santana. Feira de Santana, BA, Brasil | pt_BR |
Affilliation | Faculty of Pharmaceutical Sciences. University of São Paulo. São Paulo, SP, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil | pt_BR |
Subject | 7-hydroxycoumarin | pt_BR |
Subject | Antiinflammatory | pt_BR |
Subject | Antinociception | pt_BR |
Subject | Antipyretic | pt_BR |
Subject | Chronic pain | pt_BR |
Subject | Gastric toxicity | pt_BR |