Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/7807
ANTINOCICEPTIVE AND ANTI-INFLAMMATORY PROPERTIES OF 7-HYDROXYCOUMARIN IN EXPERIMENTAL ANIMAL MODELS: POTENTIAL THERAPEUTIC FOR THE CONTROL OF INFLAMMATORY CHRONIC PAIN.
Antiinflammatory
Antinociception
Antipyretic
Chronic pain
Gastric toxicity
10.1211/jpp/62.02.0008
Author
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / State University of Feira de Santana. Feira de Santana, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Paraíba. Paraíba, JP, Brasil
Federal University of Paraíba. Paraíba, JP, Brasil
State University of Feira de Santana. Feira de Santana, BA, Brasil
Faculty of Pharmaceutical Sciences. University of São Paulo. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Paraíba. Paraíba, JP, Brasil
Federal University of Paraíba. Paraíba, JP, Brasil
State University of Feira de Santana. Feira de Santana, BA, Brasil
Faculty of Pharmaceutical Sciences. University of São Paulo. São Paulo, SP, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil
Abstract
Objectives In the present study we investigated the antinociceptive, anti-inflammatory
and antipyretic effects of 7-hydroxycoumarin (7-HC) in animal models.
Methods The effects of oral 7-HC were tested against acetic acid-induced writhing,
formalin test, tail flick test, complete Freund’s adjuvant (CFA)-induced hypernociception,
carrageenan-induced paw oedema, lipopolysaccharide-induced fever and the rota rod test.
Key findings 7-HC (3–60 mg/kg) produced a dose-related antinociception against acetic
acid-induced writhing in mice and in the formalin test. In contrast, treatment with 7-HC
did not prevent thermal nociception in the tail flick test. A single treatment with 7-HC,
60 mg/kg, produced a long-lasting antinociceptive effect against CFA-induced hypernociception,
a chronic inflammatory pain stimulus. Notably, at 60 mg/kg per day over 4 days the
administration of 7-HC produced a continuous antinociceptive effect against CFA-induced
hypernociception. 7-HC (30–120 mg/kg) produced anti-inflammatory and antipyretic
effects against carrageenan-induced inflammation and lipopolysaccharide-induced fever,
respectively. Moreover, 7-HC was found to be safe with respect to ulcer induction. In the
rota rod test, 7-HC-treated mice did not show any motor performance alterations.
Conclusions The prolonged antinociceptive and anti-inflammatory effects of 7-HC, in
association with its low ulcerogenic activity, indicate that this molecule might be a good
candidate for development of new drugs for the control of chronic inflammatory pain and
fever.
Keywords
7-hydroxycoumarinAntiinflammatory
Antinociception
Antipyretic
Chronic pain
Gastric toxicity
Publisher
Royal Pharmaceutical Society of Great Britain
Citation
BARROS, T. A. de A. et al. Antinociceptive and anti-inflammatory properties of 7-hydroxycoumarin in experimental animal models: potential therapeutic for the control of inflammatory chronic pain. Journal of Pharmacy and Pharmacology, v. 62, p. 205–213, 2010.ISSN
2042-715810.1211/jpp/62.02.0008
Share