Author | Sousa, Fábio Castro | |
Author | Silva, Moacir Paranhos | |
Author | Sherlock, Ítalo Rodrigues de Araújo | |
Author | Paixão, Mariza S | |
Author | Pontes-de-Carvalho, Lain Carlos | |
Author | dosSantos, Washington Luis Conrado | |
Access date | 2013-02-01T18:16:14Z | |
Available date | 2013-02-01T18:16:14Z | |
Document date | 2001 | |
Citation | SOUSA, F. C. et al. Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan. Memórias do Instituto Oswaldo Cruz, v. 96, n. 7, p.997-999, 2001. | pt_BR |
ISSN | 0074-0276 | |
URI | https://www.arca.fiocruz.br/handle/icict/6289 | |
Language | eng | pt_BR |
Rights | open access | |
Title | Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan | pt_BR |
Type | Article | pt_BR |
Abstract | In this study, the ability of maxadilan and Lutzomyia longipalpis salivary gland lysate to enhance the infection of CBA mice by Leishmania major and of BALB/c mice by L. braziliensis was tested. No difference was observed between sizes of lesion in CBA mice infected with L. major and treated or not with salivary gland lysate or maxadilan, although they were injected in concentrations that induced cutaneous vasodilation. Although parasites were more frequently observed in foot pads and spleens of animals treated with maxadilan than in the animals treated with salivary gland lysate or saline, the differences were small and not statistically significant. The lesions in BALB/c mice infected with L. braziliensis and treated with maxadilan were slightly larger than in animals that received Leishmania alone. Such differences disappeared 14 weeks after infection, and were statistically significant only in one of two experiments. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunologia Molecular e Celular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunologia Molecular e Celular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunologia Molecular e Celular. Salvador, BA, Brasil | pt_BR |
Affilliation | Secretaria da Saúde do Estado da Bahia. Laboratório Central. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil | pt_BR |
Subject | Lutzomyia longipalpis saliva | pt_BR |
Subject | Maxadilan | pt_BR |
Subject | Leishmania major | pt_BR |
Subject | Leishmania braziliensis | pt_BR |
Subject | Vasodilation | pt_BR |
DeCS | Leishmaniose Cutânea/parasitologia | pt_BR |
DeCS | Psychodidae/química | pt_BR |
DeCS | Vasodilatadores/farmacologia | pt_BR |
DeCS | Extratos de Tecidos/farmacologia | pt_BR |
DeCS | Leishmania/patogenicidade | pt_BR |
DeCS | Leishmaniose Cutânea/imunologia | pt_BR |
DeCS | Leishmaniose Cutânea/patologia | pt_BR |
DeCS | Psychodidae/efeitos de drogas | pt_BR |
DeCS | Camundongos Endogâmicos BALB C | pt_BR |
DeCS | Leishmania braziliensis/patogenicidade | pt_BR |
DeCS | Leishmania major | pt_BR |
DeCS | Glândulas Salivares/química | pt_BR |
DeCS | Glândulas Salivares/efeitos de drogas | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Camundongos | pt_BR |