Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/6289
Title: Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan
Authors: Sousa, Fábio Castro
Silva, Moacir Paranhos
Sherlock, Ítalo Rodrigues de Araújo
Paixão, Mariza S
Pontes-de-Carvalho, Lain Carlos
dosSantos, Washington Luis Conrado
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunologia Molecular e Celular. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunologia Molecular e Celular. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunologia Molecular e Celular. Salvador, Bahia, Brasil
Secretaria da Saúde do Estado da Bahia. LACEN. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, Bahia, Brasil
Abstract: In this study, the ability of maxadilan and Lutzomyia longipalpis salivary gland lysate to enhance the infection of CBA mice by Leishmania major and of BALB/c mice by L. braziliensis was tested. No difference was observed between sizes of lesion in CBA mice infected with L. major and treated or not with salivary gland lysate or maxadilan, although they were injected in concentrations that induced cutaneous vasodilation. Although parasites were more frequently observed in foot pads and spleens of animals treated with maxadilan than in the animals treated with salivary gland lysate or saline, the differences were small and not statistically significant. The lesions in BALB/c mice infected with L. braziliensis and treated with maxadilan were slightly larger than in animals that received Leishmania alone. Such differences disappeared 14 weeks after infection, and were statistically significant only in one of two experiments.
Keywords: Lutzomyia longipalpis saliva
Maxadilan
Leishmania major
Leishmania braziliensis
Vasodilation
DeCS: Leishmaniose Cutânea/parasitologia
Psychodidae/química
Vasodilatadores/farmacologia
Extratos de Tecidos/farmacologia
Leishmania/patogenicidade
-Leishmaniose Cutânea/imunologia
Leishmaniose Cutânea/patologia
Psychodidae/efeitos de drogas
Camundongos Endogâmicos BALB C
Leishmania braziliensis/patogenicidade
Leishmania major
Glândulas Salivares/química
Glândulas Salivares/efeitos de drogas
Animais
Camundongos
Issue Date: 2001
Citation: SOUSA, F. C. et al. Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan. Memórias do Instituto Oswaldo Cruz, v. 96, n. 7, p.997-999, 2001.
ISSN: 0074-0276
Appears in Collections:CPqGM - Artigos de Periódicos

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