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2030-12-31
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EARLY AND LATE ACUTE LUNG INJURY AND THEIR ASSOCIATION WITH DISTAL ORGAN DAMAGE IN MURINE MALARIA
Lung mechanics
Histology
Respiratory-distress-syndrome
Cerebral malaria
Falciparum-malaria
Author
Affilliation
Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil.
Federal University of Rio de Janeiro. Carlos Chagas Filho Institute of Biophysics. Laboratory of Pulmonary Investigation. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil.
University of São Paulo. Faculty of Medicine. Department of Pathology. São Paulo, SP, Brazil.
Federal University of Rio de Janeiro. Carlos Chagas Filho Institute of Biophysics. Laboratory of Pulmonary Investigation. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Center for Technological Development in Health. Rio de Janeiro, RJ, Brasil.
Federal University of Rio de Janeiro. Carlos Chagas Filho Institute of Biophysics. Laboratory of Pulmonary Investigation. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil.
University of São Paulo. Faculty of Medicine. Department of Pathology. São Paulo, SP, Brazil.
Federal University of Rio de Janeiro. Carlos Chagas Filho Institute of Biophysics. Laboratory of Pulmonary Investigation. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Institute of Pharmaceutical Technology - Farmanguinhos. Laboratory of Applied Pharmacology. Rio de Janeiro, RJ, Brazil.
Oswaldo Cruz Foundation. Center for Technological Development in Health. Rio de Janeiro, RJ, Brasil.
Abstract
Severe malaria is characterised by cerebral oedema, acute lung injury (ALI) and multiple organ dysfunctions, however, the mechanisms of lung and distal organ damage need to be better clarified. Ninety-six C57BL/6 mice were injected intraperitoneally with 5×10(6)Plasmodium berghei ANKA-infected erythrocytes or saline. At day 1, Plasmodium berghei infected mice presented greater number of areas with alveolar collapse, neutrophil infiltration and interstitial oedema associated with lung mechanics impairment, which was more severe at day 1 than day 5. Lung tumour necrosis factor-α and chemokine (C-X-C motif) ligand 1 levels were higher at day 5 compared to day 1. Lung damage occurred in parallel with distal organ injury at day 1; nevertheless, lung inflammation and the presence of malarial pigment in distal organs were more evident at day 5. In conclusion, ALI develops prior to the onset of cerebral malaria symptoms. Later during the course of infection, the established systemic inflammatory response increases distal organ damage.
Keywords
CytokinesLung mechanics
Histology
Respiratory-distress-syndrome
Cerebral malaria
Falciparum-malaria
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