Author | Pimentel, João Paulo | |
Author | Chaves, Daniel Gonçalves | |
Author | Araújo, Ana Ruth Silva | |
Author | Araújo, Erbênia Maria Martins de | |
Author | Fraporti, Liziara da Silva | |
Author | Neves, Walter Luiz Lima | |
Author | Tarragô, Andrea Monteiro | |
Author | Torres, Katia Luz | |
Author | Gentz, Solange Henschke Lima | |
Author | Carvalho, Andréa Teixeira de | |
Author | Martins Filho, Olindo Assis | |
Author | Malheiro, Adriana | |
Access date | 2023-07-06T13:32:58Z | |
Available date | 2023-07-06T13:32:58Z | |
Document date | 2013 | |
Citation | PIMENTEL, João Paulo et al. Anti-inflammatory/regulatory cytokine microenvironment mediated by IL-4 and IL-10 coordinates the immune response in hemophilia A patients infected chronically with hepatitis C virus. Journal of Medical Virology, v. 85, n. 6, p. 1009-1018, 2013. | en_US |
ISSN | 0146-6615 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/59435 | |
Language | eng | en_US |
Publisher | Wiley | en_US |
Rights | restricted access | en_US |
Title | Anti-inflammatory/regulatory cytokine microenvironment mediated by IL-4 and IL-10 coordinates the immune response in hemophilia A patients infected chronically with Hepatitis C virus | en_US |
Type | Article | en_US |
DOI | 10.1002/jmv.23554 | |
Abstract | In the past decades patients with hemophiliawere infected commonly by hepatitis C virus(HCV) and a significant number of patients areinfected chronically. Focusing on the role ofthe immune system for controlling and ormaintaining HCV infection, the leukocyte andcytokine profiles of peripheral blood fromhemophilia A patients and other patients withand without HCV infection were studied. Theresults demonstrated that hemophilia A is char-acterized by a general state of circulating leuko-cytes activation along with an overall increasein the frequency of IL-6 and IL-10 with decreaseof IL-8 and IL-12. HCV infection of patientswith hemophilia A does not influence furtherthe activation state of circulating leukocytesbut is accompanied by lower levels of alaninetransaminase (ALT) and a prominent anti-inflammatory/regulatory serum cytokine pat-tern, mediated by IL-4 and IL-10. Additionally,the results demonstrated that hemophilia Apatients infected with HCV displaying No/Lowantibody response to C33c and C22 have signif-icant lower viral load and higher serum levelsof IL-12 and IL-4. This finding suggests that thedifferential RIBA reactivity to C33c/C22 HCVcore proteins may have a putative value as aprognostic biomarker for the infection in hemo-philia A patients. | en_US |
Affilliation | Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil / Oswaldo Cruz Foundation. Research Center Leonidas and Maria Deane. Manaus, AM, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Research Center René Rachou. Belo Horizonte, MG, Brazil / Foundation of Hematology and Hemotherapy of Minas Gerais. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil. | en_US |
Affilliation | Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil. | en_US |
Affilliation | Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil. | en_US |
Affilliation | Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil / Federal University Federal of Amazonas. Post Graduation Program in Basic and Applied Immunology. Manaus, AM, Brazil. | en_US |
Affilliation | Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil. | en_US |
Affilliation | Foundation of Oncology Control of Amazonas. Manaus, AM, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Research Center René Rachou. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Research Center René Rachou. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Research Center René Rachou. Belo Horizonte, MG, Brazil. | en_US |
Affilliation | Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil / Federal University Federal of Amazonas. Post Graduation Program in Basic and Applied Immunology. Manaus, AM, Brazil. | en_US |
Subject | Hemophilia A | en_US |
Subject | HCV | en_US |
Subject | Eukocyte activation | en_US |
Subject | Cytokines | en_US |
Subject | RIBA | en_US |
Embargo date | 2099-12-31 | |