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2099-12-31
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ANTI-INFLAMMATORY/REGULATORY CYTOKINE MICROENVIRONMENT MEDIATED BY IL-4 AND IL-10 COORDINATES THE IMMUNE RESPONSE IN HEMOPHILIA A PATIENTS INFECTED CHRONICALLY WITH HEPATITIS C VIRUS
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Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil / Oswaldo Cruz Foundation. Research Center Leonidas and Maria Deane. Manaus, AM, Brazil.
Oswaldo Cruz Foundation. Research Center René Rachou. Belo Horizonte, MG, Brazil / Foundation of Hematology and Hemotherapy of Minas Gerais. Belo Horizonte, MG, Brazil.
Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil.
Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil.
Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil.
Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil / Federal University Federal of Amazonas. Post Graduation Program in Basic and Applied Immunology. Manaus, AM, Brazil.
Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil.
Foundation of Oncology Control of Amazonas. Manaus, AM, Brazil.
Oswaldo Cruz Foundation. Research Center René Rachou. Belo Horizonte, MG, Brazil.
Oswaldo Cruz Foundation. Research Center René Rachou. Belo Horizonte, MG, Brazil.
Oswaldo Cruz Foundation. Research Center René Rachou. Belo Horizonte, MG, Brazil.
Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil / Federal University Federal of Amazonas. Post Graduation Program in Basic and Applied Immunology. Manaus, AM, Brazil.
Oswaldo Cruz Foundation. Research Center René Rachou. Belo Horizonte, MG, Brazil / Foundation of Hematology and Hemotherapy of Minas Gerais. Belo Horizonte, MG, Brazil.
Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil.
Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil.
Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil.
Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil / Federal University Federal of Amazonas. Post Graduation Program in Basic and Applied Immunology. Manaus, AM, Brazil.
Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil.
Foundation of Oncology Control of Amazonas. Manaus, AM, Brazil.
Oswaldo Cruz Foundation. Research Center René Rachou. Belo Horizonte, MG, Brazil.
Oswaldo Cruz Foundation. Research Center René Rachou. Belo Horizonte, MG, Brazil.
Oswaldo Cruz Foundation. Research Center René Rachou. Belo Horizonte, MG, Brazil.
Foundation of Hematology and Hemotherapy of Amazonas. Manaus, AM, Brazil / Federal University Federal of Amazonas. Post Graduation Program in Basic and Applied Immunology. Manaus, AM, Brazil.
Abstract
In the past decades patients with hemophiliawere infected commonly by hepatitis C virus(HCV) and a significant number of patients areinfected chronically. Focusing on the role ofthe immune system for controlling and ormaintaining HCV infection, the leukocyte andcytokine profiles of peripheral blood fromhemophilia A patients and other patients withand without HCV infection were studied. Theresults demonstrated that hemophilia A is char-acterized by a general state of circulating leuko-cytes activation along with an overall increasein the frequency of IL-6 and IL-10 with decreaseof IL-8 and IL-12. HCV infection of patientswith hemophilia A does not influence furtherthe activation state of circulating leukocytesbut is accompanied by lower levels of alaninetransaminase (ALT) and a prominent anti-inflammatory/regulatory serum cytokine pat-tern, mediated by IL-4 and IL-10. Additionally,the results demonstrated that hemophilia Apatients infected with HCV displaying No/Lowantibody response to C33c and C22 have signif-icant lower viral load and higher serum levelsof IL-12 and IL-4. This finding suggests that thedifferential RIBA reactivity to C33c/C22 HCVcore proteins may have a putative value as aprognostic biomarker for the infection in hemo-philia A patients.
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