Author | Souza, Silvia Maria de | |
Author | Santos, Luciano de Souza | |
Author | Silva, Valdenizia Rodrigues | |
Author | Soares, Milena Botelho Pereira | |
Author | Bezerra, Daniel Pereira | |
Author | Gois, Roberto Wagner da Silva | |
Author | Silva, Horlando Carlota da | |
Author | Santiago, Gilvandete Maria Pinheiro | |
Author | Militao, Gardenia Carmen Gadelha | |
Access date | 2023-06-15T19:48:23Z | |
Available date | 2023-06-15T19:48:23Z | |
Document date | 2023 | |
Citation | SOUZA, Silvia Maria de et al. Natural Dibenzo[b,f]oxepines, Pacharin and Bauhiniastatin-1, Isolated from Bauhinia acuruana Induce Apoptosis on Breast Cancer Cells via MCL-1 Protein Reduction. Planta Medica, v. 89, n.3, p. 1-9, 2023. | en_US |
ISSN | 1439-0221 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/59050 | |
Sponsorship | Fundação de Amparo a Ciência e Tecnologia do Estado de Pernambuco (FACEPE).
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). | en_US |
Language | eng | en_US |
Publisher | Thieme Gruppe | en_US |
Rights | restricted access | en_US |
Subject in Portuguese | Bauhinia acuruana | en_US |
Subject in Portuguese | Fabaceae | en_US |
Subject in Portuguese | Pacharin | en_US |
Subject in Portuguese | Bauhiniastatin-1 | en_US |
Subject in Portuguese | Adenocarcinoma de mama | en_US |
Subject in Portuguese | MCL-1 | en_US |
Subject in Portuguese | Bcl-xL | en_US |
Subject in Portuguese | Apoptose | en_US |
Title | Natural dibenzo[b,f] oxepines, pacharin and bauhiniastatin-1, isolated from bauhinia acuruana induce apoptosis on breast cancer cells via MCL-1 protein reduction | en_US |
Type | Article | en_US |
DOI | 10.1055/a-1910-5776 | |
Abstract | Herein, we describe the antiproliferative effects of two natural dibenzo [b,f]oxepines, pacharin and bauhiniastatin-1, isolated from Bauhinia acuruana on a breast cancer cell line and the mode of action underlying the cytotoxicity. Both compounds were cytotoxic in a panel of six tumor lines analyzed by the MTT assay, and IC50 values ranged from 7.8 to 45.1 µM, including human breast adenocarcinoma (MCF-7) cells. In contrast, none of the compounds were cytotoxic on normal human peripheral blood mononuclear cells (IC50 > 100 µM). Human breast adenocarcinoma (MCF-7) cells treated with pacharin or bauhiniastatin-1 20 µM for 24 h presented a reduction in cell volume and intensification of chromatin condensation, DNA fragmentation, and apoptotic cells. These findings became more evident after 48 h of exposure. Antiapoptotic B-cell lymphoma-2 family members, such as myeloid cell leukemia-1 and B-cell lymphoma-extra large, are important targets in cancer cells since their overexpression confers resistance to cancer treatments. A significant reduction of the myeloid cell leukemia-1 protein levels in human breast adenocarcinoma (MCF-7) cells after 24 h of treatment with pacharin or bauhiniastatin-1 at 20 µM was observed, while the B-cell lymphoma-extra large protein content was reduced in bauhiniastatin-1-treated cells at 40 µM only. The cytotoxic effects of pacharin and bauhiniastatin-1 are likely linked to myeloid cell leukemia-1 inhibition, which leads to the apoptosis of breast adenocarcinoma cells. | en_US |
Affilliation | Universidade Federal de Pernambuco. Centro de Biociências. Departamento de Fisiologia e Farmacologia. Recife, PE, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Instituto SENAI de Inovação em Sistemas Avançados de Saúde. SENAI CIMATEC, Salvador, BA, Brasil. | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil. | en_US |
Affilliation | Instituto Federal do Ceará. Campus Acaraú. Acaraú, CE, Brasil / Universidade Federal do Ceará. Programa de Pós-Graduação em Química. Fortaleza, CE, Brasil. | en_US |
Affilliation | Universidade Federal do Ceará. Programa de Pós-Graduação em Química. Fortaleza, CE, Brasil. | en_US |
Affilliation | Universidade Federal do Ceará. Programa de Pós-Graduação em Química. Fortaleza, CE, Brasil / Universidade Federal do Ceará. Departamento de Farmácia. Fortaleza, CE, Brasil. | en_US |
Affilliation | Universidade Federal de Pernambuco. Centro de Biociências. Departamento de Fisiologia e Farmacologia. Recife, PE, Brasil. | en_US |
Subject | Bauhinia acuruana | en_US |
Subject | Fabaceae | en_US |
Subject | Pacharin | en_US |
Subject | Bauhiniastatin‑1 | en_US |
Subject | Breast adenocarcinoma | en_US |
Subject | MCL‑1 | en_US |
Subject | Bcl‑xL | en_US |
Subject | Apoptosis | en_US |
DeCS | Fabaceae | en_US |
DeCS | Adenocarcinoma | en_US |
DeCS | Mama | en_US |
DeCS | Proteína de Sequência 1 de Leucemia de Células Mieloides | en_US |
DeCS | Proteína bcl-X | en_US |
DeCS | Apoptose | en_US |
Embargo date | 2030-12-31 | |