Author | Neira-Goulart, Milena | |
Author | Sá, Nathalia Beatriz Ramos de | |
Author | Ribeiro-Alves, Marcelo | |
Author | Perazzo, Hugo | |
Author | Geraldo, Kim Mattos | |
Author | Ribeiro, Maria Pia Diniz | |
Author | Cardoso, Sandra Wagner | |
Author | Grinsztejn, Beatriz | |
Author | Veloso, Valdiléa G. | |
Author | Gomes, Larissa Rodrigues | |
Author | Cazote, Andressa da Silva | |
Author | Almeida, Dalziza Victalina de | |
Author | Giacoia-Gripp, Carmem Beatriz Wagner | |
Author | Côrtes, Fernanda Heloise | |
Author | Morgado, Mariza Gonçalves | |
Access date | 2023-06-13T00:20:04Z | |
Available date | 2023-06-13T00:20:04Z | |
Document date | 2023 | |
Citation | NEIRA-GOULART, Milena et al. Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil. Gene, p. 1-11, May 2023. | en_US |
ISSN | 0378-1119 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/58991 | |
Description | Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. | en_US |
Description | The study protocol was approved by the Ethics Committee of the National Institute of Infectology Evandro Chagas (INI)/Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro, Brazil, under approval number CAAE: 32449420.4.1001.5262. All procedures were performed in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national). | |
Sponsorship | The study was supported by Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro - FAPERJ (Grant number SEI-260003/002689/2020; SEI- 260003/013002/2021 and SEI260003/019710/2022) and INOVA FIOCRUZ/Fundação Oswaldo Cruz (Grant number 48401996705881). Hugo Perazzo is recipient of FAPERJ (E-26/201.351/2021), Mariza Gonçalves Morgado is recipient of CNPQ (314064/2018-4) and FAPERJ (E-26/201.177/2021), and Beatriz Grinsztejn is recipient of CNPQ (305789/2019-8) and FAPERJ (E-26/202.915/2018). The funding agencies played no role in the design of the study, data collection, analysis, or interpretation, nor in writing the manuscript. | en_US |
Language | eng | en_US |
Publisher | Elsevier | en_US |
Rights | open access | |
Title | Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil | en_US |
Type | Article | |
DOI | 10.1016/j.gene.2023.147325 | |
Abstract | COVID-19 has a broad spectrum of clinical manifestations. We assessed the impact of single nucleotide polymorphisms (SNPs) of inflammasome genesas risk factors for progression toCOVID-19 critical outcomes, such as mechanical ventilation support (MVS) or death.The study included 451 hospitalized individuals followed up at the INI/FIOCRUZ, Rio de Janeiro, Brazil, from 06/2020 to 03/2021. SNPs genotyping was determined by Real-Time PCR. We analyzed risk factors for progression to MVS (n = 174[38.6 %]) or death (n = 175[38.8 %])as a result of COVID-19 by Cox proportional hazardmodels.Slower progression toMVSwas associated with allele G (aHR = 0.66;P = 0.005) or the genotype G/G (aHR = 0.391;P = 0.006) in the NLRP3 rs10754558 or the allele G (aHR = 0.309;P = 0.004) in the IL1βrs1143634, while C allele in the NLRP3 rs4612666 (aHR = 2.342;P = 0.006) or in the rs10754558 (aHR = 2.957;P = 0.005) were associated with faster progression to death. Slower progression to death was associated to allele G (aHR = 0.563;P = 0.006) or the genotype A/G (aHR = 0.537;P = 0.005) in the CARD8 rs6509365; the genotype A/C in the IFI16 rs1101996 (aHR = 0.569;P = 0.011); the genotype T/T (aHR = 0.394;P = 0.004) or allele T (aHR = 0.68;P = 0.006) in the NLRP3 rs4612666, and the genotype G/G (aHR = 0.326;P = 0.005) or allele G (aHR = 0,68;P = 0.014) in the NLRP3 rs10754558. Our results suggest that inflammasome genetic variations might influence the critical clinical course of COVID-19. | en_US |
Affilliation | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of AIDS & Molecular Immunolog. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of AIDS & Molecular Immunolog. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. Laboratory of Clinical Research on STD/AIDS. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. Laboratory of Clinical Research on STD/AIDS. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. Laboratory of Clinical Research on STD/AIDS. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. Laboratory of Clinical Research on STD/AIDS. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. Laboratory of Clinical Research on STD/AIDS. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. Laboratory of Clinical Research on STD/AIDS. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. National Institute of Infectology Evandro Chagas. Laboratory of Clinical Research on STD/AIDS. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Center of Technological Development in Health. National Institute of Science and Technological for Innovation on Neglected Population Diseases. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of AIDS & Molecular Immunolog. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of AIDS & Molecular Immunolog. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of AIDS & Molecular Immunolog. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of AIDS & Molecular Immunolog. Rio de Janeiro, RJ, Brazil. | en_US |
Affilliation | Oswaldo Cruz Foundation. Oswaldo Cruz Institute. Laboratory of AIDS & Molecular Immunolog. Rio de Janeiro, RJ, Brazil. | en_US |
Subject | COVID-19 | en_US |
Subject | Inflammasome single nucleotide polymorphisms (SNPs) | en_US |
Subject | Risk factors | en_US |
e-ISSN | 1879-0038 | |