Author | Gazzinelli, Isabella Cristina Hirako | |
Author | Assis, Patrícia A. | |
Author | Galvão Filho, Bruno | |
Author | Luster, Andrew D. | |
Author | Antonelli, Lis Ribeiro do Valle | |
Author | Gazzinelli, Ricardo Tostes | |
Access date | 2023-05-15T12:50:52Z | |
Available date | 2023-05-15T12:50:52Z | |
Document date | 2019 | |
Citation | HIRAKO, Isabella Cristina et al. Monocyte-derived dendritic cells in malária. Curr Opin Microbiol., v. 52, p. 139–150, 2019. doi: 10.1016/j.mib.2019.08.002 | en_US |
ISSN | 1369-5274 | en_US |
URI | https://www.arca.fiocruz.br/handle/icict/58382 | |
Language | eng | en_US |
Publisher | Current Biology | en_US |
Rights | open access | en_US |
Title | Monocyte-derived dendritic cells in malaria | en_US |
Type | Article | en_US |
DOI | 10.1016/j.mib.2019.08.002 | |
Abstract | The pathogenesis of malaria is a multifactorial syndrome associated with a deleterious inflammatory response that is responsible for many of the clinical manifestations. While dendritic cells (DCs) play a critical role in initiating acquired immunity and host resistance to infection, they also play a pathogenic role in inflammatory diseases. In our recent studies, we found in different rodent malaria models that the monocyte-derived DCs (MO-DCs) become, transiently, a main DC population in spleens and inflamed non-lymphoid organs. These studies suggest that acute infection with P. berghei promotes the differentiation of splenic monocytes into inflammatory monocytes (iMOs) and thereafter into MO-DCs that play a pathogenic role by promoting inflammation and tissue damage. The recruitment of MO-DCs to the lungs and brain are dependent on expression of CCR4 and CCR5, respectively, and expression of respective chemokine ligands in each organ. Once they reach the target organ the MO-DCs produce the CXCR3 ligands (CXCL9 and CXCL10), recruit CD8+ T cells, and produce toxic metabolites that play an important role in the development of experimental cerebral malaria (ECM) and acute respiratory distress syndrome (ARDS). | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/University of Massachusetts Medical School. Worcester, MA, USA | en_US |
Affilliation | University of Massachusetts Medical School. Worcester, MA, USA | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Massachusetts General Hospital. Boston, MA, USA/Harvard Medical School. Boston, MA, USA | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil | en_US |
Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/University of Massachusetts Medical School. Worcester, MA, USA | en_US |
Subject | monocytes | en_US |
Subject | inflammatory monocytes | en_US |
Subject | monocyte derived dendritic cells | en_US |
Subject | macrophages | en_US |
Subject | dendritic cells | en_US |
Subject | T lymphocytes | en_US |
Subject | chemokines | en_US |
Subject | Plasmodium | en_US |
Subject | malaria | en_US |
Subject | pathogenesis | en_US |