Author | Botelho, Anne Jardim | |
Author | Raff, Sophia | |
Author | Rodrigues, Renato de Avila | |
Author | Hoffman, Heather J. | |
Author | Diemert, David Joseph | |
Author | Oliveira, Rodrigo Corrêa de | |
Author | Bethony, Jeffrey Michael | |
Author | Gazzinelli, Maria Flavia | |
Access date | 2021-12-29T14:04:12Z | |
Available date | 2021-12-29T14:04:12Z | |
Document date | 2008 | |
Citation | BOTELHO, Anne Jardim et al. Hookworm, Ascaris lumbricoides infection and polyparasitism associated with poor cognitive performance in Brazilian schoolchildren. Tropical Medicine and International Health, v. 13, n. 8, p. 994-1004, 2008. doi:10.1111/j.1365-3156.2008.02103.x | pt_BR |
ISSN | 1360-2276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/50560 | |
Sponsorship | BILL AND MELINDA GATES FOUNDATION | pt_BR |
Language | eng | pt_BR |
Publisher | Blackwell Publishing | pt_BR |
Rights | open access | pt_BR |
Title | Hookworm, Ascaris lumbricoides infection and polyparasitism associated with poor cognitive performance in Brazilian schoolchildren | pt_BR |
Alternative title | Ankylostome, infection à A. lumbricoides et polyparasitisme associés à une mauvaise performance cognitive chez des écoliers brésiliens | pt_BR |
Alternative title | Anquilostoma, infección por A. lumbricoides y poliparasitismo asociado con un desempeño cognitivo pobre en niños escolares en Brasil | pt_BR |
Type | Article | pt_BR |
DOI | 10.1111/j.1365-3156.2008.02103.x | |
Abstract | OBJECTIVE To investigate the relationship between hookworm and Ascaris lumbricoides infection and performance on three subsets of the Wechsler Intelligence Scale for Children - third edition (WISC-III) (Digit Span, Arithmetic and Coding) and Raven Colored Progressive Matrices. METHODS Cross-sectional study of 210 children between the ages of 6 and 11 years in Americaninhas, Minas Gerais, Brazil. Separate proportional odds models were used to measure the association between the intensity of helminth infections and poor performance on each of the four cognitive tests. RESULTS After adjusting for sex, age, socioeconomic status and other helminth infections, moderate-to-high-intensity hookworm infection was associated with poor performance on the WISC-III Coding subtest [OR = 3.20; 95% confidence interval (CI) = 1.43-7.17], low intensity of hookworm infection was associated with poor performance on the WISC-III Coding subtest [odds ratio (OR) = 3.71; 95% CI = 1.80-7.66] and moderate-to-high-intensity A. lumbricoides infection was associated with poor performance on the Raven test (OR = 2.03; 95% CI = 1.04-3.99), all in comparison with uninfected children. Children co-infected with A. lumbricoides infection and hookworm infection had greater odds of poor performance on some WISC-III subtests than children with only A. lumbricoides infection. CONCLUSIONS These findings suggest that hookworm infection may be associated with poorer concentration and information processing skills, as measured on the WISC-III Coding subtest, and that A. lumbricoides infection may be associated with poorer general intelligence, as measured through the Raven Colored Progressive Matrices. This study also presents evidence that polyparasitized children experience worse cognitive outcomes than children with only one helminth infection | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Setor de Nutrição e Dietética. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Department of Microbiology, George Washington University, Immunology and Tropical Medicine, Washington DC, USA/ Department of Epidemiology and Biostatistics, George Washington University, Washington DC, USA | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Department of Epidemiology and Biostatistics, George Washington University, Washington DC, USA | pt_BR |
Affilliation | Department of Microbiology, George Washington University, Immunology and Tropical Medicine, Washington DC, USA/Sabin Vaccine Institute. Washington DC, USA | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Department of Microbiology, George Washington University, Immunology and Tropical Medicine, Washington DC, USA | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Escola de Enfermagem. Belo Horizonte, MG, Brazil | pt_BR |
Subject | hookworm | pt_BR |
Subject | Ascaris lumbricoides | pt_BR |
Subject | cognitive function | pt_BR |
Subject | polyparasitism | pt_BR |
Subject | school children | pt_BR |
Subject | Brazil | pt_BR |