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https://www.arca.fiocruz.br/handle/icict/50560
HOOKWORM, ASCARIS LUMBRICOIDES INFECTION AND POLYPARASITISM ASSOCIATED WITH POOR COGNITIVE PERFORMANCE IN BRAZILIAN SCHOOLCHILDREN
Anquilostoma, infección por A. lumbricoides y poliparasitismo asociado con un desempeño cognitivo pobre en niños escolares en Brasil
Alternative title
Ankylostome, infection à A. lumbricoides et polyparasitisme associés à une mauvaise performance cognitive chez des écoliers brésiliensAnquilostoma, infección por A. lumbricoides y poliparasitismo asociado con un desempeño cognitivo pobre en niños escolares en Brasil
Author
Affilliation
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Hospital das Clínicas. Setor de Nutrição e Dietética. Belo Horizonte, MG, Brazil
Department of Microbiology, George Washington University, Immunology and Tropical Medicine, Washington DC, USA/ Department of Epidemiology and Biostatistics, George Washington University, Washington DC, USA
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Department of Epidemiology and Biostatistics, George Washington University, Washington DC, USA
Department of Microbiology, George Washington University, Immunology and Tropical Medicine, Washington DC, USA/Sabin Vaccine Institute. Washington DC, USA
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Department of Microbiology, George Washington University, Immunology and Tropical Medicine, Washington DC, USA
Universidade Federal de Minas Gerais. Escola de Enfermagem. Belo Horizonte, MG, Brazil
Department of Microbiology, George Washington University, Immunology and Tropical Medicine, Washington DC, USA/ Department of Epidemiology and Biostatistics, George Washington University, Washington DC, USA
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Department of Epidemiology and Biostatistics, George Washington University, Washington DC, USA
Department of Microbiology, George Washington University, Immunology and Tropical Medicine, Washington DC, USA/Sabin Vaccine Institute. Washington DC, USA
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Department of Microbiology, George Washington University, Immunology and Tropical Medicine, Washington DC, USA
Universidade Federal de Minas Gerais. Escola de Enfermagem. Belo Horizonte, MG, Brazil
Abstract
OBJECTIVE To investigate the relationship between hookworm and Ascaris lumbricoides infection and performance on three subsets of the Wechsler Intelligence Scale for Children - third edition (WISC-III) (Digit Span, Arithmetic and Coding) and Raven Colored Progressive Matrices. METHODS Cross-sectional study of 210 children between the ages of 6 and 11 years in Americaninhas, Minas Gerais, Brazil. Separate proportional odds models were used to measure the association between the intensity of helminth infections and poor performance on each of the four cognitive tests. RESULTS After adjusting for sex, age, socioeconomic status and other helminth infections, moderate-to-high-intensity hookworm infection was associated with poor performance on the WISC-III Coding subtest [OR = 3.20; 95% confidence interval (CI) = 1.43-7.17], low intensity of hookworm infection was associated with poor performance on the WISC-III Coding subtest [odds ratio (OR) = 3.71; 95% CI = 1.80-7.66] and moderate-to-high-intensity A. lumbricoides infection was associated with poor performance on the Raven test (OR = 2.03; 95% CI = 1.04-3.99), all in comparison with uninfected children. Children co-infected with A. lumbricoides infection and hookworm infection had greater odds of poor performance on some WISC-III subtests than children with only A. lumbricoides infection. CONCLUSIONS These findings suggest that hookworm infection may be associated with poorer concentration and information processing skills, as measured on the WISC-III Coding subtest, and that A. lumbricoides infection may be associated with poorer general intelligence, as measured through the Raven Colored Progressive Matrices. This study also presents evidence that polyparasitized children experience worse cognitive outcomes than children with only one helminth infection
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