Author | Costa-Ferro, Zaquer Suzana Munhoz | |
Author | Lima, Pedro Antônio Schmidt do Prado | |
Author | Onsten, Guilherme Ary | |
Author | Oliveira, Gutierre Neves | |
Author | Brito, Guilherme Camargo | |
Author | Ghilardi, Isadora Machado | |
Author | Santos, Paula Gabrielli dos | |
Author | Bertinatto, Ricardo Jean | |
Author | Silva, Daniele Vieira da | |
Author | Salamoni, Simone Denise | |
Author | Machado, Denise Cantarelli | |
Author | Cruz, Ivana Beatrice Mânica da | |
Author | Souza, Bruno Solano de Freitas | |
Author | Costa, Jaderson Costa da | |
Access date | 2021-11-16T18:01:04Z | |
Available date | 2021-11-16T18:01:04Z | |
Document date | 2021 | |
Citation | COSTA-FERRO, Zaquer Suzana Munhoz et al. Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules. Progress in Neuro-Psychopharmacology and Biological Psychiatry, v. 113, 2021. | pt_BR |
ISSN | 0278-5846 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/49847 | |
Description | a Brain Institute (BraIns), Pontificia Universidade Cat´
olica do Rio Grande do Sul, Porto Alegre, RS, Brazil b Center for Biotechnology and Cell Therapy, Sao ˜ Rafael Hospital, Bahia, Brazil c D’Or Institute for Research and Education (IDOR), Rio de Janeiro, Brazil d Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Bahia, Brazil e Graduate Program in Pharmacology, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil | |
Sponsorship | CNPq, FAPERGS, PUCRS, and Pandurata
Alimentos Ltda. The funding organizations played no role in the design
or conduct of the study, data interpretation, or article writing. Jaderson
Costa da Costa is funded by CNPq (research productivity, PQ1A). | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Células mononucleares | pt_BR |
Subject in Portuguese | Medula óssea | pt_BR |
Subject in Portuguese | Tansplantação | pt_BR |
Subject in Portuguese | Inflamação | pt_BR |
Subject in Portuguese | Depressão | pt_BR |
Subject in Portuguese | Tratamento | pt_BR |
Title | Bone marrow mononuclear cell transplant prevents rat depression and modulates inflammatory and neurogenic molecules | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.pnpbp.2021.110455 | |
Abstract | Introduction: Major depressive disorder is associated with chronic inflammation and deficient production of
brain-derived neurotrophic factor (BDNF). Bone marrow mononuclear cell (BMMC) transplantation has an antiinflammatory
effect and has been proven effective in restoring non-depressive behavior. This study investigated
whether BMMC transplantation can prevent the development of depression or anxiety in chronic mild stress
(CMS), as well as its effect on inflammatory and neurogenic molecules.
Method: Three groups of animals were compared: BMMC-transplanted animals subjected to CMS for 45 days,
CMS non-transplanted rats, and control animals. After the CMS period, the three groups underwent the following
behavioral tests: sucrose preference test (SPT), eating-related depression test (ERDT), social avoidance test (SAT),
social interaction test (SIT), and elevated plus maze test (EPMT). Transplanted cell tracking and measurement of
the expression of high-mobility group box 1 (HMGB1), interleukin-1β (IL-1β), tumor necrosis factor (TNFα), and
BDNF were performed on brain and spleen tissues.
Results: BMMC transplantation prevented the effects of CMS in the SPT, ERDT, SAT, and SIT, while prevention
was less pronounced in the EPMT. It was found to prevent increased HMGB-1 expression induced by CMS in the
hippocampus and spleen, increase BDNF expression in both tissues, and prevent increased IL-1β expression in the
hippocampus alone, while no effect of the transplant was observed in the TNFα expression. In addition, no
transplanted cells were found in either the brain or spleen.
Conclusions: BMMC transplantation prevents the development of depression and anxiety-like behavior triggered
by CMS. It could prevent increased HMGB-1 and IL-1β expression in the hippocampus and increased BDNF
expression in the same tissue. Cell treatment represents a further perspective in the research and treatment of
depression and possible mood disorders. | pt_BR |
Affilliation | "Múltipla ver em Notas" | pt_BR |
Subject | Bone marrow mononuclear cells | pt_BR |
Subject | Transplantation | pt_BR |
Subject | Depression treatment | pt_BR |
Subject | HMGB1 | pt_BR |
Subject | BDNF | pt_BR |
Subject | Inflammation | pt_BR |