Author | Oliveira, Elaine Cristina de | |
Author | Fonseca, Vagner | |
Author | Xavier, Joilson | |
Author | Adelino, Talita Émile Ribeiro | |
Author | Claro, Inga Morales | |
Author | Fabri, Allison | |
Author | Macario, Eduardo Marques | |
Author | Viniski, Ana Elisa | |
Author | Souza, Claudio Luis Campos | |
Author | Costa, Evanil Sebastiana Gomes da | |
Author | Sousa, Claudia Soares de | |
Author | Duarte, Flávia Guimarães Dias | |
Author | Medeiros, Arnaldo Correia de | |
Author | Melo, Carlos Frederico Campelo de Albuquerque e | |
Author | Cunha, Rivaldo Venancio | |
Author | Moura, Noely Fabiana Oliveira de | |
Author | Filippis, Ana Maria Bispo de | |
Author | Oliveira, Tulio de | |
Author | Lourenço, José | |
Author | Abreu, Andre Luiz de | |
Author | Alcantara, Luis Carlos Junior | |
Author | Giovanetti, Marta | |
Access date | 2021-08-26T13:28:24Z | |
Available date | 2021-08-26T13:28:24Z | |
Document date | 2021 | |
Citation | OLIVEIRA, Elaine Cristina de et al. Short report: Introduction of chikungunya virus ECSA genotype into the Brazilian Midwest and its dispersion through the Americas. Plos NeglTrop Dis, v. 15, n. 4, e0009290, Apr. 2021. | pt_BR |
ISSN | 1935-2727 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/48761 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | |
Subject in Portuguese | Chikungunya | pt_BR |
Subject in Portuguese | Genótipo | pt_BR |
Subject in Portuguese | virus ECSA | pt_BR |
Subject in Portuguese | Dispersão atráves América | pt_BR |
Title | Short report: Introduction of chikungunya virus ECSA genotype into the Brazilian Midwest and its dispersion through the Americas | pt_BR |
Type | Article | |
DOI | 10.1371/journal.pntd.0009290 | |
Abstract | Since introduction into Brazil in 2014, chikungunya virus (CHIKV) has presented sustained
transmission, although much is unknown about its circulation in the midwestern states.
Here, we analyze 24 novel partial and near complete CHIKV genomes from Cuiaba, an
urban metropolis located in the Brazilian midwestern state of Mato Grosso (MT).
Nanopore technology was used for sequencing CHIKV complete genomes. Phylogenetic
and epidemiological approaches were used to explore the recent spatio-temporal evolution
and spread of the CHIKV-ECSA genotype in Midwest Brazil as well as in the Americas.
Epidemiological data revealed a reduction in the number of reported cases over 2018–
2020, likely as a consequence of a gradual accumulation of herd-immunity. Phylogeo graphic reconstructions revealed that at least two independent introductions of the ECSA
lineage occurred in MT from a dispersion event originating in the northeastern region and
suggest that the midwestern Brazilian region appears to have acted as a source of virus
transmission towards Paraguay, a bordering South American country. Since introduction into Brazil in 2014, chikungunya virus (CHIKV) has presented sustained
transmission, although much is unknown about its circulation in the midwestern states.
Here, we analyze 24 novel partial and near complete CHIKV genomes from Cuiaba, an
urban metropolis located in the Brazilian midwestern state of Mato Grosso (MT).
Nanopore technology was used for sequencing CHIKV complete genomes. Phylogenetic
and epidemiological approaches were used to explore the recent spatio-temporal evolution
and spread of the CHIKV-ECSA genotype in Midwest Brazil as well as in the Americas.
Epidemiological data revealed a reduction in the number of reported cases over 2018–
2020, likely as a consequence of a gradual accumulation of herd-immunity. Phylogeo graphic reconstructions revealed that at least two independent introductions of the ECSA
lineage occurred in MT from a dispersion event originating in the northeastern region and
suggest that the midwestern Brazilian region appears to have acted as a source of virus
transmission towards Paraguay, a bordering South American country.Since introduction into Brazil in 2014, chikungunya virus (CHIKV) has presented sustained
transmission, although much is unknown about its circulation in the midwestern states.
Here, we analyze 24 novel partial and near complete CHIKV genomes from Cuiaba, an
urban metropolis located in the Brazilian midwestern state of Mato Grosso (MT).
Nanopore technology was used for sequencing CHIKV complete genomes. Phylogenetic
and epidemiological approaches were used to explore the recent spatio-temporal evolution
and spread of the CHIKV-ECSA genotype in Midwest Brazil as well as in the Americas.
Epidemiological data revealed a reduction in the number of reported cases over 2018–
2020, likely as a consequence of a gradual accumulation of herd-immunity. Phylogeo graphic reconstructions revealed that at least two independent introductions of the ECSA
lineage occurred in MT from a dispersion event originating in the northeastern region and
suggest that the midwestern Brazilian region appears to have acted as a source of virus
transmission towards Paraguay, a bordering South American country. Our results show a complex dynamic of transmission between epidemic seasons and
suggest a possible role of Brazil as a source for international dispersion of the CHIKV-ECSA
genotype to other countries in the Americas. | pt_BR |
Affilliation | Laboratório Central de Saúde Pública do Estado de Mato Grosso. Cuiaba, MT, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Laboratóio de Genética Celular e Molecular. Belo Horizonte, MG, Brasil / KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), College of Health Sciences, University of KwaZuluNatal, Durban 4001, South Africa / Ministério da Saúde. Secretaria de Vigilância em Saúde. Coordenação Geral dos Laboratórios de Saúde Pública. Brasíllia, DF, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Laboratóio de Genética Celular e Molecular. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Universidade de São Paulo. Faculdade de Medicina. Instituto de Medicina Tropical. São Paulo, SP, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil. | pt_BR |
Affilliation | Laboratório Central de Saúde Pública do Estado de Mato Grosso. Cuiaba, MT, Brasil. | pt_BR |
Affilliation | Laboratório Central de Saúde Pública do Estado de Mato Grosso. Cuiaba, MT, Brasil. | pt_BR |
Affilliation | Secretaria de Saúde de Cuiaba. MT Brasil. | pt_BR |
Affilliation | Secretaria de Saúde de Cuiaba. MT Brasil. | pt_BR |
Affilliation | Secretaria de Saúde de Cuiaba. MT Brasil. | pt_BR |
Affilliation | Ministério da Saúde. Secretaria de Vigilância em Saúde. Brasília, DF, Brasil. | pt_BR |
Affilliation | Organização Pan-Americana da Saúde/ Organização Mundial da Saúde. Brasília, DF, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Bio-Manguinhos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Ministério da Saúde.. Coordenação Geral de Arboviroses. Brasíllia, DF, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), College of Health Sciences, University of KwaZuluNatal. Durban 4001, South Africa | pt_BR |
Affilliation | University of Oxford. Department of Zoology. Oxford, UK. | pt_BR |
Affilliation | Ministério da Saúde.Coordenação Geral dos Laboratórios de Saúde Pública / Secretaria de Vigilância em Saúde. Brasília, DF, Brasil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Laboratóio de Genética Celular e Molecular. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil.. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Laboratóio de Genética Celular e Molecular. Belo Horizonte, MG, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Chikungunya virus ECSA | pt_BR |
Subject | Genotype | pt_BR |
Subject | Brazilian Midwest | pt_BR |
Subject | Dispersion | pt_BR |
Subject | Through America | pt_BR |
e-ISSN | 1935-2735 | |