Author | Leyrolle, Quentin | |
Author | Decoeur, F. | |
Author | Briere, G. | |
Author | Amadieu, C. | |
Author | Quadros, A. R. A. A. | |
Author | Voytyuk, I. | |
Author | Lacabanne, C. | |
Author | Benmamar-Badel, A. | |
Author | Bourel, J. | |
Author | Aubert, A. | |
Author | Sere, A. | |
Author | Chain, F. | |
Author | Schwendimann, L. | |
Author | Matrot, B. | |
Author | Bourgeois, T. | |
Author | Grégoire, S. | |
Author | Leblanc, J. G. | |
Author | De Leblanc, A. De Moreno | |
Author | Langella, P. | |
Author | Fernandes, Gabriel da Rocha | |
Author | Bretillon, L. | |
Author | Joffre, C. | |
Author | Uricaru, R. | |
Author | Thebault, P. | |
Author | Gressens, P. | |
Author | Chatel, J. M. | |
Author | Layé, S. | |
Author | Nadjar, A. | |
Access date | 2020-09-21T15:23:21Z | |
Available date | 2020-09-21T15:23:21Z | |
Document date | 2020 | |
Citation | LEYROLLE, Quentin et al. Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime. Neuropsychopharmacol, p. 1-24, 2020. | pt_BR |
ISSN | 0893-133X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/43523 | |
Language | eng | pt_BR |
Publisher | Nature Publishing Group | pt_BR |
Rights | restricted access | pt_BR |
Title | Maternal dietary omega-3 deficiency worsens the deleterious effects of prenatal inflammation on the gut-brain axis in the offspring across lifetime | pt_BR |
Type | Article | pt_BR |
DOI | 10.1038/s41386-020-00793-7 | |
Abstract | Maternal immune activation (MIA) and poor maternal nutritional habits are risk factors for the occurrence of neurodevelopmental disorders (NDD). Human studies show the deleterious impact of prenatal inflammation and low n-3 polyunsaturated fatty acid (PUFA) intake on neurodevelopment with long-lasting consequences on behavior. However, the mechanisms linking maternal nutritional status to MIA are still unclear, despite their relevance to the etiology of NDD. We demonstrate here that low maternal n-3 PUFA intake worsens MIA-induced early gut dysfunction, including modification of gut microbiota composition and higher local inflammatory reactivity. These deficits correlate with alterations of microglia-neuron crosstalk pathways and have long-lasting effects, both at transcriptional and behavioral levels. This work highlights the perinatal period as a critical time window, especially regarding the role of the gut-brain axis in neurodevelopment, elucidating the link between MIA, poor nutritional habits, and NDD. | pt_BR |
Affilliation | University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France / Université de Paris, NeuroDiderot, Inserm. Paris, France. | pt_BR |
Affilliation | University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France. | pt_BR |
Affilliation | University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux / Université de Paris, NeuroDiderot, Inserm. Paris, France / CNRS, Bordeaux INP, LaBRI. Talence, France. | pt_BR |
Affilliation | University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France. | pt_BR |
Affilliation | University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France. | pt_BR |
Affilliation | University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France. | pt_BR |
Affilliation | University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France. | pt_BR |
Affilliation | University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France. | pt_BR |
Affilliation | University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France. | pt_BR |
Affilliation | University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France. | pt_BR |
Affilliation | University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France. | pt_BR |
Affilliation | University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France. | pt_BR |
Affilliation | Université de Paris. NeuroDiderot, Inserm. Paris, France. | pt_BR |
Affilliation | Université de Paris. NeuroDiderot, Inserm. Paris, France. | pt_BR |
Affilliation | Université de Paris. NeuroDiderot, Inserm. Paris, France. | pt_BR |
Affilliation | Centre des Sciences du Goût et de l’Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, Dijon, France. | pt_BR |
Affilliation | CERELA-CONICET. San Miguel de Tucuman. Argentina. | pt_BR |
Affilliation | CERELA-CONICET. San Miguel de Tucuman. Argentina | pt_BR |
Affilliation | Micalis Institute, INRAE, AgroParisTech, Université Paris-Saclay. France. | pt_BR |
Affilliation | Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Centre des Sciences du Goût et de l’Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, Dijon, France. | pt_BR |
Affilliation | University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France. | pt_BR |
Affilliation | CNRS, Bordeaux INP, LaBRI. Talence, France. | pt_BR |
Affilliation | CNRS, Bordeaux INP, LaBRI. Talence, France. | pt_BR |
Affilliation | Université de Paris, NeuroDiderot, Inserm. Paris, France / Centre for the Developing Brain, Department of Division of Imaging Sciences and Biomedical Engineering, King’s College London, King’s Health Partners, St. Thomas’ Hospital. London, UK. | pt_BR |
Affilliation | Micalis Institute, INRAE, AgroParisTech, Université Paris-Saclay. France. | pt_BR |
Affilliation | University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France. | pt_BR |
Affilliation | University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France. | pt_BR |
Subject | Experimental models of disease | pt_BR |
Subject | Risk factors | pt_BR |