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https://www.arca.fiocruz.br/handle/icict/43523
MATERNAL DIETARY OMEGA-3 DEFICIENCY WORSENS THE DELETERIOUS EFFECTS OF PRENATAL INFLAMMATION ON THE GUT-BRAIN AXIS IN THE OFFSPRING ACROSS LIFETIME
Author
Leyrolle, Quentin
Decoeur, F.
Briere, G.
Amadieu, C.
Quadros, A. R. A. A.
Voytyuk, I.
Lacabanne, C.
Benmamar-Badel, A.
Bourel, J.
Aubert, A.
Sere, A.
Chain, F.
Schwendimann, L.
Matrot, B.
Bourgeois, T.
Grégoire, S.
Leblanc, J. G.
De Leblanc, A. De Moreno
Langella, P.
Fernandes, Gabriel da Rocha
Bretillon, L.
Joffre, C.
Uricaru, R.
Thebault, P.
Gressens, P.
Chatel, J. M.
Layé, S.
Nadjar, A.
Decoeur, F.
Briere, G.
Amadieu, C.
Quadros, A. R. A. A.
Voytyuk, I.
Lacabanne, C.
Benmamar-Badel, A.
Bourel, J.
Aubert, A.
Sere, A.
Chain, F.
Schwendimann, L.
Matrot, B.
Bourgeois, T.
Grégoire, S.
Leblanc, J. G.
De Leblanc, A. De Moreno
Langella, P.
Fernandes, Gabriel da Rocha
Bretillon, L.
Joffre, C.
Uricaru, R.
Thebault, P.
Gressens, P.
Chatel, J. M.
Layé, S.
Nadjar, A.
Affilliation
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France / Université de Paris, NeuroDiderot, Inserm. Paris, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux / Université de Paris, NeuroDiderot, Inserm. Paris, France / CNRS, Bordeaux INP, LaBRI. Talence, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
Université de Paris. NeuroDiderot, Inserm. Paris, France.
Université de Paris. NeuroDiderot, Inserm. Paris, France.
Université de Paris. NeuroDiderot, Inserm. Paris, France.
Centre des Sciences du Goût et de l’Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, Dijon, France.
CERELA-CONICET. San Miguel de Tucuman. Argentina.
CERELA-CONICET. San Miguel de Tucuman. Argentina
Micalis Institute, INRAE, AgroParisTech, Université Paris-Saclay. France.
Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
Centre des Sciences du Goût et de l’Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, Dijon, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
CNRS, Bordeaux INP, LaBRI. Talence, France.
CNRS, Bordeaux INP, LaBRI. Talence, France.
Université de Paris, NeuroDiderot, Inserm. Paris, France / Centre for the Developing Brain, Department of Division of Imaging Sciences and Biomedical Engineering, King’s College London, King’s Health Partners, St. Thomas’ Hospital. London, UK.
Micalis Institute, INRAE, AgroParisTech, Université Paris-Saclay. France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux / Université de Paris, NeuroDiderot, Inserm. Paris, France / CNRS, Bordeaux INP, LaBRI. Talence, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
Université de Paris. NeuroDiderot, Inserm. Paris, France.
Université de Paris. NeuroDiderot, Inserm. Paris, France.
Université de Paris. NeuroDiderot, Inserm. Paris, France.
Centre des Sciences du Goût et de l’Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, Dijon, France.
CERELA-CONICET. San Miguel de Tucuman. Argentina.
CERELA-CONICET. San Miguel de Tucuman. Argentina
Micalis Institute, INRAE, AgroParisTech, Université Paris-Saclay. France.
Rene Rachou Institute. Oswaldo Cruz Foundation. Belo Horizonte, MG, Brazil.
Centre des Sciences du Goût et de l’Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, Dijon, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
CNRS, Bordeaux INP, LaBRI. Talence, France.
CNRS, Bordeaux INP, LaBRI. Talence, France.
Université de Paris, NeuroDiderot, Inserm. Paris, France / Centre for the Developing Brain, Department of Division of Imaging Sciences and Biomedical Engineering, King’s College London, King’s Health Partners, St. Thomas’ Hospital. London, UK.
Micalis Institute, INRAE, AgroParisTech, Université Paris-Saclay. France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
University Bordeaux. INRAE, Bordeaux INP. NutriNeuro. Bordeaux, France.
Abstract
Maternal immune activation (MIA) and poor maternal nutritional habits are risk factors for the occurrence of neurodevelopmental disorders (NDD). Human studies show the deleterious impact of prenatal inflammation and low n-3 polyunsaturated fatty acid (PUFA) intake on neurodevelopment with long-lasting consequences on behavior. However, the mechanisms linking maternal nutritional status to MIA are still unclear, despite their relevance to the etiology of NDD. We demonstrate here that low maternal n-3 PUFA intake worsens MIA-induced early gut dysfunction, including modification of gut microbiota composition and higher local inflammatory reactivity. These deficits correlate with alterations of microglia-neuron crosstalk pathways and have long-lasting effects, both at transcriptional and behavioral levels. This work highlights the perinatal period as a critical time window, especially regarding the role of the gut-brain axis in neurodevelopment, elucidating the link between MIA, poor nutritional habits, and NDD.
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