Author | Gomes, Regis Bernardo Brandim | |
Author | Brodskyn, Claudia Ida | |
Author | Oliveira, Camila Indiani de | |
Author | Costa, Jackson Mauricio Lopes | |
Author | Miranda, José Carlos | |
Author | Caldas, Arlene de Jesus Mendes | |
Author | Valenzuela, Jesus G | |
Author | Barral Netto, Manoel | |
Author | Barral, Aldina Maria Prado | |
Access date | 2012-07-18T20:56:40Z | |
Available date | 2012-07-18T20:56:40Z | |
Document date | 2002 | |
Citation | GOMES, R.B. et al. Seroconversion against Lutzomyia longipalpis saliva concurrent with the development of anti-Leishmania chagasi delayed-type hypersensitivity. Journal of Infectious Disease, v. 186, n. 10, p. 1530-4, nov. 2002. | pt_BR |
ISSN | 0022-1899 | |
URI | https://www.arca.fiocruz.br/handle/icict/4198 | |
Language | eng | pt_BR |
Rights | open access | |
Title | Seroconversion against Lutzomyia longipalpis saliva concurrent with the development of anti-Leishmania chagasi delayed-type hypersensitivity | pt_BR |
Type | Article | |
Abstract | Antibody responses to salivary gland sonicate (SGS) from Lutzomyia longipalpis were investigated using serum samples from individuals living in an area where visceral leishmaniasis is endemic. Individuals were classified into 2 groups, according to the alteration of their responses to Leishmania chagasi antigen over the course of 6 months. Group 1 included children who experienced anti-L. chagasi seroconversion from negative to positive; group 2 included children who experienced delayed-type hypersensitivity (DTH) response to L. chagasi antigen conversion from negative to positive. Individuals who experienced seroconversion against L. chagasi antigens did not have increased anti-saliva antibody response, whereas those who developed a positive anti-L. chagasi DTH response had increased immunoglobulin (Ig) G, IgG1 and IgE anti-SGS antibody levels. Despite wide variation, serum samples from individuals in group 2 recognized more bands in SGS than did those from individuals in group 1. This simultaneous appearance of anti-saliva humoral response and anti-L. chagasi cell-mediated immunity supports the hypothesis that induction of immune response against SGS can facilitate induction of a protective response against leishmaniasis | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal do Maranhão. São Luis, MA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, Maryland | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
DeCS | Doenças Endêmicas | pt_BR |
DeCS | Hipersensibilidade Tardia/imunologia | pt_BR |
DeCS | Imunoglobulina G/imunologia | pt_BR |
DeCS | Leishmania/imunologia | pt_BR |
DeCS | Leishmaniose/imunologia | pt_BR |
DeCS | Psychodidae/imunologia | pt_BR |
DeCS | Formação de Anticorpos/imunologia | pt_BR |
DeCS | Criança | pt_BR |
DeCS | Humanos | pt_BR |
DeCS | Imunidade Celular/imunologia | pt_BR |
DeCS | Leishmaniose/epidemiologia | pt_BR |
DeCS | Glândulas Salivares/imunologia | pt_BR |