Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/4198
Title: Seroconversion against Lutzomyia longipalpis saliva concurrent with the development of anti-Leishmania chagasi delayed-type hypersensitivity
Other Titles: Seroconversion against Lutzomyia longipalpis saliva concurrent with the development of anti-Leishmania chagasi delayed-type hypersensitivity
Authors: Gomes, Regis Bernardo Brandim
Brodskyn, Claudia Ida
Oliveira, Camila Indiani de
Costa, Jackson Mauricio Lopes
Miranda, José Carlos
Caldas, Arlene de Jesus Mendes
Valenzuela, Jesus G
Barral Netto, Manoel
Barral, Aldina Maria Prado
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Universidade Federal do Maranhão. São Luis, Maranhão, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
National Institute of Allergy and Infectious Diseases. National Institutes of Health. Bethesda, Maryland
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, Bahia, Brasil
Abstract: Antibody responses to salivary gland sonicate (SGS) from Lutzomyia longipalpis were investigated using serum samples from individuals living in an area where visceral leishmaniasis is endemic. Individuals were classified into 2 groups, according to the alteration of their responses to Leishmania chagasi antigen over the course of 6 months. Group 1 included children who experienced anti-L. chagasi seroconversion from negative to positive; group 2 included children who experienced delayed-type hypersensitivity (DTH) response to L. chagasi antigen conversion from negative to positive. Individuals who experienced seroconversion against L. chagasi antigens did not have increased anti-saliva antibody response, whereas those who developed a positive anti-L. chagasi DTH response had increased immunoglobulin (Ig) G, IgG1 and IgE anti-SGS antibody levels. Despite wide variation, serum samples from individuals in group 2 recognized more bands in SGS than did those from individuals in group 1. This simultaneous appearance of anti-saliva humoral response and anti-L. chagasi cell-mediated immunity supports the hypothesis that induction of immune response against SGS can facilitate induction of a protective response against leishmaniasis
DeCS: Doenças Endêmicas
Hipersensibilidade Tardia/imunologia
Imunoglobulina G/imunologia
Leishmania/imunologia
Leishmaniose/imunologia
Psychodidae/imunologia
Formação de Anticorpos/imunologia
Criança
Humanos
Imunidade Celular/imunologia
Leishmaniose/epidemiologia
Glândulas Salivares/imunologia
Issue Date: 2002
Citation: GOMES, R.B. et al. Seroconversion against Lutzomyia longipalpis saliva concurrent with the development of anti-Leishmania chagasi delayed-type hypersensitivity. Journal of Infectious Disease, v. 186, n. 10, p. 1530-4, nov. 2002.
Date of defense: 2002
Place of defense: Salvador
Department: Centro de Pesquisas Gonçalo Moniz
Defense institution: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz
ISSN: 0022-1899
Appears in Collections:IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Gomes RB Seroconversion against Lutzomyia....pdf151.68 kBAdobe PDFThumbnail
View/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.