Author | Macedo, Cristiana Santos de | |
Author | Lara, Flavio Alves | |
Author | Pinheiro, Roberta Olmo | |
Author | Schmitz, Veronica | |
Author | Pinho, Marcia de Berrêdo | |
Author | Pereira, Geraldo Moura | |
Author | Pessolani, Maria Cristina Vidal | |
Access date | 2020-04-27T17:36:52Z | |
Available date | 2020-04-27T17:36:52Z | |
Document date | 2020 | |
Citation | MACEDO, Cristiana Santos de et al. New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved]. F1000Research, v. 9, n. 70, p. 1-10, Jan. 2020. | pt_BR |
ISSN | 2046-1402 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/40993 | |
Language | eng | pt_BR |
Publisher | F1000Research | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Hanseníase | pt_BR |
Subject in Portuguese | Tolerância a doenças | pt_BR |
Subject in Portuguese | Metabolismo | pt_BR |
Subject in Portuguese | Resposta imune | pt_BR |
Subject in Portuguese | Lipídios | pt_BR |
Subject in Portuguese | Células T regulador | pt_BR |
Subject in Portuguese | Micobactéia | pt_BR |
Title | New insights into the pathogenesis of leprosy: contribution of subversion of host cell metabolism to bacterial persistence, disease progression, and transmission [version 1; peer review: 2 approved] | pt_BR |
Type | Article | pt_BR |
DOI | 10.12688/f1000research.21383.1 | |
Abstract | Chronic infection by the obligate intracellular pathogen Mycobacterium
leprae may lead to the development of leprosy. Of note, in the lepromatous
clinical form of the disease, failure of the immune system to constrain
infection allows the pathogen to reproduce to very high numbers with
minimal clinical signs, favoring transmission. The bacillus can modulate
cellular metabolism to support its survival, and these changes directly
influence immune responses, leading to host tolerance, permanent
disease, and dissemination. Among the metabolic changes, upregulation of
cholesterol, phospholipids, and fatty acid biosynthesis is particularly
important, as it leads to lipid accumulation in the host cells (macrophages
and Schwann cells) in the form of lipid droplets, which are sites of
polyunsaturated fatty acid–derived lipid mediator biosynthesis that
modulate the inflammatory and immune responses. In Schwann cells,
energy metabolism is also subverted to support a lipogenic environment.
Furthermore, effects on tryptophan and iron metabolisms favor pathogen
survival with moderate tissue damage. This review discusses the
implications of metabolic changes on the course of M. leprae infection and
host immune response and emphasizes the induction of regulatory T cells,
which may play a pivotal role in immune modulation in leprosy. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Leprosy | pt_BR |
Subject | Disease tolerance | pt_BR |
Subject | Metabolism | pt_BR |
Subject | Immune response | pt_BR |
Subject | Regulatory T cells | pt_BR |
Subject | Lipids | pt_BR |
Subject | Mycobacterium | pt_BR |