Author | Bello, Gonzalo | |
Author | Guimarães, Monick L. | |
Author | Morgado, Mariza G. | |
Access date | 2019-12-31T20:16:43Z | |
Available date | 2019-12-31T20:16:43Z | |
Document date | 2006 | |
Citation | BELLO, Gonzalo; GUIMARÁES, Monick L.; MORGADO, Mariza G. Evolutionary history of HIV-1 subtype B and F infections in Brazil. AIDS, v. 20, p. 763-768, 2006. | pt_BR |
ISSN | 0269-9370 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/38919 | |
Language | eng | pt_BR |
Publisher | Lippincott, Williams & Wilkins | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | AIDS | pt_BR |
Subject in Portuguese | Subtipo B | pt_BR |
Subject in Portuguese | Subtipo F | pt_BR |
Subject in Portuguese | HIV-1 | pt_BR |
Subject in Portuguese | Origem epídêmica | pt_BR |
Subject in Portuguese | Relógio molecular | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Title | Evolutionary history of HIV-1 subtype B and F infections in Brazil | pt_BR |
Type | Article | pt_BR |
DOI | 10.1097/01.aids.0000216377.84313.52 | |
Abstract | Objective: To reconstruct the onset date of the HIV-1 B and F epidemics in Brazil based on virus diversification over time. Design: We studied HIV-1 env V3 sequences (210nt) with a known sampling year isolated from HIV-1 positive patients from Brazil between 1989 and 1997: 101 subtype B sequences and 41 subtype F sequences. Methods: HIV-1 V3 env sequences were grouped by year of collection and the relationship between the sampling years of HIV-1 sequences and their genetic distance to the reconstructed common ancestor (intra-population divergence) or to other sequences from the same year (intra-population diversity) was examined by using linear regression analysis. Results: Regression analysis of nucleotide distances, revealed a highly significant positive correlation between sampling years of subtype B and F V3 sequences and their intra-population divergence (P < 0.001) or diversity (P < 0.0001). In both subtype populations, the divergence and diversity increased at a rate of 0.5 and 0.9% per year, respectively. Considering these evolutionary rates, we estimate the onset of the subtype B and F HIV-1 epidemics in Brazil during early 1970s and early 1980s, respectively. Conclusions: The consistent correlation between divergence and diversity of the V3 sequences with their sampling years indicates that the molecular clock is operational in the evolution of the HIV-1 in Brazil’s epidemic, and show that subtypes B and F are evolving at a similar rate over time. The dating results suggest a discontinuous introduction of these subtypes in the Brazilian population. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Brazil | pt_BR |
Subject | Subtype B | pt_BR |
Subject | Subtype F | pt_BR |
Subject | HIV-1 | pt_BR |
Subject | Epidemic origin | pt_BR |
Subject | Molecular clock | pt_BR |
e-ISSN | 1473-5571 | |
Embargo date | 2025-01-01 | |