Author | Borges, Juliana Pereira | |
Author | Mendes, Fernanda de Souza Nogueira Sardinha | |
Author | Lopes, Gabriella de Oliveira | |
Author | Sousa, Andréa Silvestre de | |
Author | Mediano, Mauro Felippe Felix | |
Author | Tibiriçá, Eduardo | |
Access date | 2019-07-10T14:41:14Z | |
Available date | 2019-07-10T14:41:14Z | |
Document date | 2018 | |
Citation | BORGES, Juliana Pereira et al. Is endothelial microvascular function equally impaired among patientswith chronic Chagas and ischemic cardiomyopathy? International Journal of Cardiology, v. 265, p. 35-37, 2018. | pt_BR |
ISSN | 0167-5273 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/33949 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Title | Is endothelial microvascular function equally impaired among patients with chronic Chagas and ischemic cardiomyopathy? | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.ijcard.2018.04.133 | |
Abstract | Background: Chronic Chagas cardiomyopathy (CCC) and cardiomyopathies due to other etiologies involve differences in pathophysiological pathways that are still unclear. Systemic microvascular abnormalities are associatedwith the pathogenesis of ischemic heart disease. However, systemic microvascular endothelial function in CCCremains to be elucidated. Thus, we compared the microvascular endothelial function of patients presentingwith CCC to those with ischemic cardiomyopathy disease. Methods: Microvascular reactivity was assessed in 21 patients with cardiomyopathy secondary to Chagas disease, 21 patients with cardiomyopathy secondary to ischemic disease and 21 healthy controls. Microvascular bloodflow was assessed in the skin of the forearm using laser speckle contrast imaging coupled with iontophoresisof acetylcholine (ACh). Results: Peak increase in forearm bloodflow with ACh iontophoresis in relation to baseline was greater in healthy controls than in patients with heart disease (controls: 162.7 ± 58.4%vs. ischemic heart disease: 74.1± 48.3% andChagas: 85.1 ± 68.1%; pb0.0001). Patients with Chagas and ischemic cardiomyopathy presented similar ACh-induced changes from baseline in skin bloodflow (p = 0.55).Conclusion:Endothelial microvascular function was equally impaired among patients with CCC and ischemic cardiomyopathy. | pt_BR |
Affilliation | State University of Rio de Janeiro. Laboratory of Physical Activity and Health Promotion. Rio de Janeiro, RJ, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil . | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Chagas heart disease | pt_BR |
Subject | Ischemic heart disease | pt_BR |
Subject | Coronary artery disease | pt_BR |
Subject | Endothelial function | pt_BR |
Subject | Cutaneous vascular conductance | pt_BR |
Subject | Microvascular flowmetry | pt_BR |
Embargo date | 2020-07-10 | |