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https://www.arca.fiocruz.br/handle/icict/33949
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ArticleCopyright
Open access
Embargo date
2020-07-10
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- INI - Artigos de Periódicos [3393]
- IOC - Artigos de Periódicos [12490]
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IS ENDOTHELIAL MICROVASCULAR FUNCTION EQUALLY IMPAIRED AMONG PATIENTS WITH CHRONIC CHAGAS AND ISCHEMIC CARDIOMYOPATHY?
Ischemic heart disease
Coronary artery disease
Endothelial function
Cutaneous vascular conductance
Microvascular flowmetry
Author
Affilliation
State University of Rio de Janeiro. Laboratory of Physical Activity and Health Promotion. Rio de Janeiro, RJ, Brazil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil .
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil .
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Abstract
Background: Chronic Chagas cardiomyopathy (CCC) and cardiomyopathies due to other etiologies involve differences in pathophysiological pathways that are still unclear. Systemic microvascular abnormalities are associatedwith the pathogenesis of ischemic heart disease. However, systemic microvascular endothelial function in CCCremains to be elucidated. Thus, we compared the microvascular endothelial function of patients presentingwith CCC to those with ischemic cardiomyopathy disease. Methods: Microvascular reactivity was assessed in 21 patients with cardiomyopathy secondary to Chagas disease, 21 patients with cardiomyopathy secondary to ischemic disease and 21 healthy controls. Microvascular bloodflow was assessed in the skin of the forearm using laser speckle contrast imaging coupled with iontophoresisof acetylcholine (ACh). Results: Peak increase in forearm bloodflow with ACh iontophoresis in relation to baseline was greater in healthy controls than in patients with heart disease (controls: 162.7 ± 58.4%vs. ischemic heart disease: 74.1± 48.3% andChagas: 85.1 ± 68.1%; pb0.0001). Patients with Chagas and ischemic cardiomyopathy presented similar ACh-induced changes from baseline in skin bloodflow (p = 0.55).Conclusion:Endothelial microvascular function was equally impaired among patients with CCC and ischemic cardiomyopathy.
Keywords
Chagas heart diseaseIschemic heart disease
Coronary artery disease
Endothelial function
Cutaneous vascular conductance
Microvascular flowmetry
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