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https://www.arca.fiocruz.br/handle/icict/31583
IN VITRO AND IN VIVO ANTI-LEUKEMIA ACTIVITY OF THE STEM BARK OF SALACIA IMPRESSIFOLIA (MIERS) A. C. SMITH (CELASTRACEAE)
Author
Rodrigues, Ana Carolina Borges da Cruz
Oliveira, Felipe P. de
Dias, Rosane Borges
Sales, Caroline Brandi Schlaepfer
Rocha, Clarissa Araújo Gurgel
Soares, Milena Botelho Pereira
Costa, Emmanoel Vilaça
Silva, Felipe Moura Araujo da
Gomes, Waldireny Rocha
Koolen, Hector Henrique Ferreira
Bezerra, Daniel Pereira
Oliveira, Felipe P. de
Dias, Rosane Borges
Sales, Caroline Brandi Schlaepfer
Rocha, Clarissa Araújo Gurgel
Soares, Milena Botelho Pereira
Costa, Emmanoel Vilaça
Silva, Felipe Moura Araujo da
Gomes, Waldireny Rocha
Koolen, Hector Henrique Ferreira
Bezerra, Daniel Pereira
Affilliation
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Federal University of Bahia. Institute of Health Sciences. Department of Biomorphology. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brazil.
Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brazil.
Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brazil.
Federal University of Amazonas. Health and Biotechnology Institute. Coari, AM, Brazil.
Amazonas State University. Metabolomics and Mass Spectrometry Research Group. Manaus, AM, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Federal University of Bahia. Institute of Health Sciences. Department of Biomorphology. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brazil.
Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brazil.
Federal University of Amazonas. Department of Chemistry. Manaus, AM, Brazil.
Federal University of Amazonas. Health and Biotechnology Institute. Coari, AM, Brazil.
Amazonas State University. Metabolomics and Mass Spectrometry Research Group. Manaus, AM, Brazil.
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
Abstract
Salacia impressifolia (Miers) A. C. Smith (family Celastraceae) is a traditional medicinal plant found in the Amazon Rainforest known as "miraruíra", "cipó-miraruíra" or "panu" and is traditionally used to treat dengue, flu, inflammation, pain, diabetes, male impotency, renal affections, rheumatism and cancer. Aim of the study: The aim of this study was to investigate in vitro and in vivo anti-leukemia activity of
the stem bark of S. impressifolia in experimental models. Materials and methods: The in vitro cytotoxic activity of
extracts, fractions and quinonemethide triterpenes (22-hydroxytingenone, tingenone and pristimerin) from the
stem bark of S. impressifolia in cultured cancer cells was determined. The in vivo antitumor activity of the ethyl
acetate extract (EAE) and of its fraction (FEAE.3) from the stem bark of S. impressifolia was assessed in C.B-17
severe combined immunodeficient (SCID) mice engrafted with human promyelocytic leukemia HL-60 cells.
Results: The extract EAE, its fraction FEAE.3, and quinonemethide triterpenes exhibited potent cytotoxicity
against cancer cell lines, including in vitro anti-leukemia activity against HL-60 and K-562 cells. Moreover,
extract EAE and its fraction FEAE.3 inhibited the in vivo development of HL-60 cells engrafted in C.B-17 SCID
mice. Tumor mass inhibition rates were measured as 40.4% and 81.5% for the extract EAE (20 mg/kg) and for its
fraction FEAE.3 (20 mg/kg), respectively. Conclusions: Ethyl acetate extract and its fraction from the stem bark of
S. impressifolia exhibit in vitro and in vivo anti-leukemia activity that can be attributed to their quinonemethide
triterpenes. These data confirm the ethnopharmacological use of this species and may contribute to the development
of a novel anticancer herbal medicine.
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