Author | Ngongondo, McNeil | |
Author | Miyahara, Sachiko | |
Author | Hughes, Michael D | |
Author | Sun, Xin | |
Author | Bisson, Gregory P | |
Author | Gupta, Amita | |
Author | Kumwenda, Johnstone | |
Author | Lavenberg, Jeffrey A | |
Author | Torres, Thiago Silva | |
Author | Nyirenda, Mulinda | |
Author | Kidonge, Katende Kenneth | |
Author | Hosseinipour, Mina C | |
Author | AIDS Clinical Trials Group A5274 (REMEMBER) Study Team | |
Access date | 2018-12-03T15:47:35Z | |
Available date | 2018-12-03T15:47:35Z | |
Document date | 2018 | |
Citation | NGONGONDO, M. et al. Hepatotoxicity during isoniazid preventive therapy and antiretroviral therapy in people living with HIV with severe immunosuppression: a secondary analysis of a multi-country open-label randomized controlled clinical trial. Journal of Acquired Immune Deficiency Syndromes, v. 78, n. 1, p. 54-61, 2018. | pt_BR |
ISSN | 1525-4135 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30363 | |
Description | A5274 was supported by the National Institute of Allergy and Infectious
Diseases of the National Institutes of Health under award numbers UM1
AI068634, UM1 AI068636, and UM1 AI106701 and also supported by
National Institute of Mental Health (NIMH), National Institute of Dental
and Craniofacial Research (NIDCR) through the AIDS Clinical Trials
Group (ACTG). The primary author was supported by the UM1
AI068634 grant (ACTG-SDAC Internship program at the Center for
Biostatistics AIDS Research). | pt_BR |
Language | por | pt_BR |
Publisher | Wolters Kluwer Health | pt_BR |
Rights | restricted access | pt_BR |
Title | Hepatotoxicity During Isoniazid Preventive Therapy and Antiretroviral Therapy in People Living With HIV With Severe Immunosuppression: A Secondary Analysis of a Multi-Country Open-Label Randomized Controlled Clinical Trial | pt_BR |
Type | Article | pt_BR |
DOI | 10.1097/QAI.0000000000001641 | |
Abstract | Hepatotoxicity associated with isoniazid preventive therapy (IPT) and antiretroviral therapy (ART) has not been well studied in severely immunosuppressed people with HIV. Our objective was to determine risk factors for hepatotoxicity in severely immunosuppressed individuals taking IPT and ART. | pt_BR |
Affilliation | UNC-Project Malawi. Lilongwe, Malawi./ Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA. | pt_BR |
Affilliation | Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA. | pt_BR |
Affilliation | Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA. | pt_BR |
Affilliation | Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA. | pt_BR |
Affilliation | University of Pennsylvania. Perelman School of Medicine. Philadelphia, PA, USA. | pt_BR |
Affilliation | Johns Hopkins University. School of Medicine. Baltimore, MD, USA. | pt_BR |
Affilliation | Johns Hopkins Project. Blantyre, Malawi. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil./ Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA. | pt_BR |
Affilliation | Johns Hopkins Project. Blantyre, Malawi. | pt_BR |
Affilliation | Case Western Research Collaboration (JCRC). Kampala, Uganda. | pt_BR |
Affilliation | UNC-Project Malawi. Lilongwe, Malawi./ North Carolina School of Medicine. Chapel Hill, NC, USA. | pt_BR |
Subject | Isoniazid | pt_BR |
Subject | ART | pt_BR |
Subject | Hepatotoxicity | pt_BR |
Subject | HIV | pt_BR |
Subject | Immunosuppression | pt_BR |
Embargo date | 2038-08-30 | |