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https://www.arca.fiocruz.br/handle/icict/30363
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2038-08-30
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- INI - Artigos de Periódicos [3394]
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HEPATOTOXICITY DURING ISONIAZID PREVENTIVE THERAPY AND ANTIRETROVIRAL THERAPY IN PEOPLE LIVING WITH HIV WITH SEVERE IMMUNOSUPPRESSION: A SECONDARY ANALYSIS OF A MULTI-COUNTRY OPEN-LABEL RANDOMIZED CONTROLLED CLINICAL TRIAL
Author
Affilliation
UNC-Project Malawi. Lilongwe, Malawi./ Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA.
Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA.
Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA.
Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA.
University of Pennsylvania. Perelman School of Medicine. Philadelphia, PA, USA.
Johns Hopkins University. School of Medicine. Baltimore, MD, USA.
Johns Hopkins Project. Blantyre, Malawi.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil./ Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA.
Johns Hopkins Project. Blantyre, Malawi.
Case Western Research Collaboration (JCRC). Kampala, Uganda.
UNC-Project Malawi. Lilongwe, Malawi./ North Carolina School of Medicine. Chapel Hill, NC, USA.
Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA.
Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA.
Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA.
University of Pennsylvania. Perelman School of Medicine. Philadelphia, PA, USA.
Johns Hopkins University. School of Medicine. Baltimore, MD, USA.
Johns Hopkins Project. Blantyre, Malawi.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil./ Harvard T. H. Chan School of Public Health. Center for Biostatistics in AIDS Research. Boston, MA, USA.
Johns Hopkins Project. Blantyre, Malawi.
Case Western Research Collaboration (JCRC). Kampala, Uganda.
UNC-Project Malawi. Lilongwe, Malawi./ North Carolina School of Medicine. Chapel Hill, NC, USA.
Abstract
Hepatotoxicity associated with isoniazid preventive therapy (IPT) and antiretroviral therapy (ART) has not been well studied in severely immunosuppressed people with HIV. Our objective was to determine risk factors for hepatotoxicity in severely immunosuppressed individuals taking IPT and ART.
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