Author | Diaz-Albiter, Hector | |
Author | Sant´Anna, Mauricio R. V. | |
Author | Genta, Fernando | |
Author | Dillon, Rod J. | |
Access date | 2018-11-06T15:12:33Z | |
Available date | 2018-11-06T15:12:33Z | |
Document date | 2012 | |
Citation | DIAZ-ALBITER, Hector; et al. Reactive Oxygen Species-mediated Immunity against Leishmania mexicana and Serratia marcescens in the Phlebotomine Sand Fly Lutzomyia longipalpis. The Journal of Biological Chemistry, v.287-, n.28, p.23995-24003, July 2012. | pt_BR |
ISSN | 0021-9258 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/29899 | |
Language | eng | pt_BR |
Publisher | American Society for Biochemistry and Molecular Biology | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Lutzomyia longipalpis | pt_BR |
Subject in Portuguese | Imunidade | pt_BR |
Subject in Portuguese | Leishmania mexicana | pt_BR |
Subject in Portuguese | Serratia marcescens | pt_BR |
Subject in Portuguese | espécies reativas de oxigênio | pt_BR |
Title | Reactive Oxygen Species-mediated Immunity against Leishmania mexicana and Serratia marcescens in the Phlebotomine Sand Fly Lutzomyia longipalpis | pt_BR |
Type | Article | pt_BR |
DOI | 10.1074/jbc.M112.376095 | |
Abstract | Background: Reactive oxygen species are part of the sand fly innate immune system.
Results: ROS production in the gut increases in response to a bacterial pathogen but not to Leishmania.
Conclusion: Sand flies tolerate the presence of Leishmania by differential response of the ROS system.
Significance: The successful use of sand flies as vehicles for Leishmania transmission relies partially on the parasite circumventing
the ROS immune response. | pt_BR |
Affilliation | Liverpool School of Tropical Medicine. Vector Group. Liverpool, UK. | pt_BR |
Affilliation | Lancaster University. Faculty of Health and Medicine. Lancashire, United Kingdom. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Lancaster University. Faculty of Health and Medicine. Lancashire, United Kingdom. | pt_BR |
Subject | Leishmania mexicana | pt_BR |
Subject | Immunity | pt_BR |
Subject | Lutzomyia longipalpis | pt_BR |
Subject | Reactive Oxygen Species | pt_BR |
Subject | Serratia marcescens | pt_BR |
e-ISSN | 1083-351X | |