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REACTIVE OXYGEN SPECIES-MEDIATED IMMUNITY AGAINST LEISHMANIA MEXICANA AND SERRATIA MARCESCENS IN THE PHLEBOTOMINE SAND FLY LUTZOMYIA LONGIPALPIS
Imunidade
Leishmania mexicana
Serratia marcescens
espécies reativas de oxigênio
Immunity
Lutzomyia longipalpis
Reactive Oxygen Species
Serratia marcescens
Affilliation
Liverpool School of Tropical Medicine. Vector Group. Liverpool, UK.
Lancaster University. Faculty of Health and Medicine. Lancashire, United Kingdom.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil.
Lancaster University. Faculty of Health and Medicine. Lancashire, United Kingdom.
Lancaster University. Faculty of Health and Medicine. Lancashire, United Kingdom.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ. Brasil.
Lancaster University. Faculty of Health and Medicine. Lancashire, United Kingdom.
Abstract
Background: Reactive oxygen species are part of the sand fly innate immune system.
Results: ROS production in the gut increases in response to a bacterial pathogen but not to Leishmania.
Conclusion: Sand flies tolerate the presence of Leishmania by differential response of the ROS system.
Significance: The successful use of sand flies as vehicles for Leishmania transmission relies partially on the parasite circumventing
the ROS immune response.
Keywords in Portuguese
Lutzomyia longipalpisImunidade
Leishmania mexicana
Serratia marcescens
espécies reativas de oxigênio
Keywords
Leishmania mexicanaImmunity
Lutzomyia longipalpis
Reactive Oxygen Species
Serratia marcescens
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