Author | Carranza-Tamayo, César O. | |
Author | Assis, Tália Santana Machado de | |
Author | Neri, Ana Teresa Basílio | |
Author | Cupolillo, Elisa | |
Author | Rabello, Ana | |
Author | Romero, Gustavo Adolfo Sierra | |
Access date | 2018-08-23T14:18:59Z | |
Available date | 2018-08-23T14:18:59Z | |
Document date | 2009 | |
Citation | CARRANZA-TAMAYO, César O. et al. Prevalence of Leishmania infection in adult HIV/AIDS patients treated in a tertiary-level care center in Brasilia, Federal District, Brazil. Transactions of the Royal Society of Tropical Medicine and Hygiene, v.103, p.743—748, Feb. 2009. | pt_BR |
ISSN | 0035-9203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/28328 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | |
Subject in Portuguese | Leishmaniose | pt_BR |
Subject in Portuguese | Leishmaniose visceral | pt_BR |
Subject in Portuguese | Leishmania chagasi | pt_BR |
Subject in Portuguese | HIV | pt_BR |
Subject in Portuguese | AIDS | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Title | Prevalence of Leishmania infection in adult HIV/AIDS patients treated in a tertiary-level care center in Brasilia, Federal District, Brazil | pt_BR |
Type | Article | |
DOI | 10.1016/j.trstmh.2009.01.014 | |
Abstract | In order to estimate the magnitude of Leishmania/HIV co-infection, patients with
HIV/AIDS at the Brasilia University Hospital, DF, Brazil were used as subjects in a cross-sectional
study. One hundred and sixty-three patients were enrolled, seven of whom had visceral leishmaniasis
(VL). One hundred and twelve patients (68.7%) were men; 155 (95.1%) had been exposed
to HIV infection through unprotected sex. The median age was 37 years (range: 20—74) and the
median CD4+ lymphocyte count was 314 cells/ l (range: 2—1600). Symptomatic patients underwent
bone marrow evaluations through direct examination of Giemsa-stained films, parasite
culture and PCR assay. Blood samples were evaluated by means of an indirect immunofluorescent
antibody test (IFAT), an ELISA using a soluble antigen of L. chagasi (ELISA), an ELISA
with the rK39 antigen (ELISA-rK39) and a PCR targeted to the kDNA region and to the internal
transcribed spacer 1 of the rDNA gene. The proportion of positive results was 2.4% for the IFAT,
12.3% for the ELISA and 4.9% for the rK39 tests. The estimated prevalence was 16%. The PCR in
the blood was positive in three patients (1.8%). The prevalence of Leishmania spp. infection is
high among HIV patients attending this Brazilian center suggesting that they should be routinely
investigated for VL infection. | pt_BR |
Affilliation | Universidade de Brasília. Laboratório de Leishmanioses do Núcleo de Medicina Tropical. Brasília, DF, Brasil / Hospital Universitário de Brasília. Brasília, DF, Brasil. | |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil. | |
Affilliation | Universidade de Brasília. Laboratório de Leishmanioses do Núcleo de Medicina Tropical. Brasília, DF, Brasil / Hospital Universitário de Brasília. Brasília, DF, Brasil. | |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmamiose. Rio de Janeiro, RJ. Brasil. | |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil. | |
Affilliation | Universidade de Brasília. Laboratório de Leishmanioses do Núcleo de Medicina Tropical. Brasília, DF, Brasil / Hospital Universitário de Brasília. Brasília, DF, Brasil. | |
Subject | Leishmaniasis | pt_BR |
Subject | Visceral leishmaniasis | pt_BR |
Subject | Leishmania chagasi | pt_BR |
Subject | HIV | pt_BR |
Subject | AIDS | pt_BR |
Subject | Brazil | pt_BR |
e-ISSN | 1878-3503 | |
Embargo date | 2030-01-01 | |