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2030-01-01
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- IOC - Artigos de Periódicos [12488]
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PREVALENCE OF LEISHMANIA INFECTION IN ADULT HIV/AIDS PATIENTS TREATED IN A TERTIARY-LEVEL CARE CENTER IN BRASILIA, FEDERAL DISTRICT, BRAZIL
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Affilliation
Universidade de Brasília. Laboratório de Leishmanioses do Núcleo de Medicina Tropical. Brasília, DF, Brasil / Hospital Universitário de Brasília. Brasília, DF, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
Universidade de Brasília. Laboratório de Leishmanioses do Núcleo de Medicina Tropical. Brasília, DF, Brasil / Hospital Universitário de Brasília. Brasília, DF, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmamiose. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
Universidade de Brasília. Laboratório de Leishmanioses do Núcleo de Medicina Tropical. Brasília, DF, Brasil / Hospital Universitário de Brasília. Brasília, DF, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
Universidade de Brasília. Laboratório de Leishmanioses do Núcleo de Medicina Tropical. Brasília, DF, Brasil / Hospital Universitário de Brasília. Brasília, DF, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Leishmamiose. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
Universidade de Brasília. Laboratório de Leishmanioses do Núcleo de Medicina Tropical. Brasília, DF, Brasil / Hospital Universitário de Brasília. Brasília, DF, Brasil.
Abstract
In order to estimate the magnitude of Leishmania/HIV co-infection, patients with
HIV/AIDS at the Brasilia University Hospital, DF, Brazil were used as subjects in a cross-sectional
study. One hundred and sixty-three patients were enrolled, seven of whom had visceral leishmaniasis
(VL). One hundred and twelve patients (68.7%) were men; 155 (95.1%) had been exposed
to HIV infection through unprotected sex. The median age was 37 years (range: 20—74) and the
median CD4+ lymphocyte count was 314 cells/ l (range: 2—1600). Symptomatic patients underwent
bone marrow evaluations through direct examination of Giemsa-stained films, parasite
culture and PCR assay. Blood samples were evaluated by means of an indirect immunofluorescent
antibody test (IFAT), an ELISA using a soluble antigen of L. chagasi (ELISA), an ELISA
with the rK39 antigen (ELISA-rK39) and a PCR targeted to the kDNA region and to the internal
transcribed spacer 1 of the rDNA gene. The proportion of positive results was 2.4% for the IFAT,
12.3% for the ELISA and 4.9% for the rK39 tests. The estimated prevalence was 16%. The PCR in
the blood was positive in three patients (1.8%). The prevalence of Leishmania spp. infection is
high among HIV patients attending this Brazilian center suggesting that they should be routinely
investigated for VL infection.
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