Author | Soares, Milena Botelho Pereira | |
Author | Brustolim, Daniele | |
Author | Santos, Luciane Amorim | |
Author | Bellintani, Moema Cortizo | |
Author | Paiva, F. P | |
Author | Ribeiro, Yvone M | |
Author | Tomassini, Therezinha Coelho Barbosa | |
Author | Santos, Ricardo Ribeiro dos | |
Access date | 2011-08-20T00:21:06Z | |
Available date | 2011-08-20T00:21:06Z | |
Document date | 2006 | |
Citation | SOARES, M. B. P. et al. Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection. International Immunopharmacology, v.6, n.3, p.408-414, 2006. | pt_BR |
ISSN | 1567-5769 | |
URI | https://www.arca.fiocruz.br/handle/icict/2800 | |
Description | Os autores gostariam de agradecer aos Drs. Augusto C. A. Mota e Washington L. C. Santos
que gentilmente ajudaram com as análises estatísticas. | pt_BR |
Sponsorship | Este trabalho foi financiado pelo CNPq, pelo
Instituto do Milênio do Semiárido(IMSEAR-MCT)
e pela FIOCRUZ (PDTIS). | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | en |
Subject in Portuguese | Imunossupressão | pt_BR |
Subject in Portuguese | Linfoproliferação | pt_BR |
Subject in Portuguese | Transplantação | pt_BR |
Title | Physalins B, F and G, seco-steroids purified from Physalis angulata L., inhibit lymphocyte function and allogeneic transplant rejection | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.intimp.2005.09.007 | |
Abstract | Physalis angulata is a solanaceae widely used in folk medicine in various tropical countries in the world. We have previously
described that seco-steroids (physalins) purified from P. angulata are potent inhibitors of macrophage activation, blocking the production of pro-inflammatory cytokines and LPS-induced lethality. Herein we investigated the immunomodulatory activities of these substances in lymphocyte proliferation and cytokine production and in transplantation. The addition of physalins B, F or G to concanavalin A-activated splenocyte cultures induced a concentration-dependent inhibition of proliferation. Physalin B also
inhibited IL-2 production by Con A-activated spleen cells. The addition of 2 Ag/ml physalin B to mixed lymphocyte reaction
(MLR) caused a 100% inhibition of proliferation. More importantly, treatment of mice with physalin B, F or G prevented the
rejection of allogeneic heterotopic heart transplant. Our results demonstrate the suppressive activity of physalins B, F and G in lymphocyte function and indicate the potential use of physalins as immunosuppressive agents for treatments of pathologies in which inhibition of immune responses is desired. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Farmanguinhos. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Farmanguinhos. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Physalin | pt_BR |
Subject | Immunosuppression | pt_BR |
Subject | Lymphoproliferation | pt_BR |
Subject | Transplantation | pt_BR |
DeCS | Animais | pt_BR |
DeCS | Proliferação de Células | pt_BR |
DeCS | Concanavalina A | pt_BR |
DeCS | Feminino | pt_BR |
DeCS | Rejeição de Enxerto | pt_BR |
DeCS | Transplante de Coração | pt_BR |
DeCS | Imunossupressores | pt_BR |
DeCS | Interleucina-2 | pt_BR |
DeCS | Linfócitos | pt_BR |
DeCS | Masculino | pt_BR |
DeCS | Camundongos | pt_BR |
DeCS | Camundongos Endogâmicos BALB C | pt_BR |
DeCS | Camundongos Endogâmicos C3H | pt_BR |
DeCS | Camundongos Endogâmicos C57BL | pt_BR |
DeCS | Camundongos Endogâmicos CBA | pt_BR |
DeCS | Mifepristona | pt_BR |
DeCS | Physalis | pt_BR |
DeCS | Secoesteróides | pt_BR |
DeCS | Baço | pt_BR |