Author | Silva, Luciana Menezes da | |
Author | Santos, Ricardo Ribeiro dos | |
Author | Soares, Milena Botelho Pereira | |
Author | Andrade, Zilton de Araújo | |
Access date | 2011-07-15T13:22:06Z | |
Available date | 2011-07-15T13:22:06Z | |
Document date | 2006 | |
Citation | SILVA, L. M. et al. Characterization of the vascular changes in schistosomal portal (pipestem) fibrosis of mice. Acta Tropica, v. 98, n. 1, p.34-42, 2006. | pt_BR |
ISSN | 0001-706X | |
URI | https://www.arca.fiocruz.br/handle/icict/2755 | |
Description | Agradecimentos a Sheilla Andrade de Oliveira, Rejane M.C. Menezes, Antonio
Carlos S. Santos e Ana Cristina Gonzalez pelo apoio técnico e Brendan Flannery pela revisão do manuscrito. | pt_BR |
Sponsorship | Este trabalho foi financiado pelo Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) e pela Fundação Oswaldo Cruz (FIOCRUZ). | pt_BR |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Schistosoma mansoni | pt_BR |
Subject in Portuguese | Fibrose Periportal | pt_BR |
Subject in Portuguese | Granuloma Periovular | pt_BR |
Subject in Portuguese | Fibrose Hepática | pt_BR |
Title | Characterization of the vascular changes in schistosomal portal (pipestem) fibrosis of mice | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.actatropica.2006.01.011 | |
Abstract | Mice chronically infected with Schistosoma mansoni develop one of two anatomical forms of hepatic lesions: severe, periportal
(pipestem) fibrosis or milder, isolated granulomas. The pathogenesis of periportal fibrosis is poorly understood. In this work we
compared mice with either periportal fibrosis or isolated granulomas to identify specific markers of severe pathology. BALB/c or
Swiss Webster mice were infected with 30 cercarie, once or six times, and liver biopsies were performed to classify the animals
into two pathological groups 16 weeks later. Sixty percent of the animals sacrificed at 20 or 24 weeks had periportal fibrosis,
15–20% had isolated granulomas and the remainder had indeterminate pathology. There was no correlation between frequency of
infections or egg burden (eggs/g liver) at 20 and 24 weeks post-infection and the development of periportal fibrosis. Livers with
periportal fibrosis at 20 or 24 weeks of infection were characterized by larger areas of fibrotic tissue and greater vascularization
compared to livers of mice with isolated granulomas. Plastic casts of the portal vein system showed marked changes in vascular
structure in mice with periportal fibrosis, including collateral vessels sprouting from the main portal branches, amputation of the
more delicate peripheral ramifications, and distortions of the medium and small branches. Vascular changes were not observed in
mice with isolated granulomas. These results suggest that the interaction between schistosome eggs and portal vascular changes is
of paramount importance in the development of pipestem fibrosis. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquis Gonçalo Moniz. Laboratórios de Patologia Experimental. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Engenharia Tecidual e Imunofarmacologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratórios de Patologia Experimental. Salvador, BA, Brasil | pt_BR |
Subject | Schistosoma mansoni | pt_BR |
Subject | Periportal (pipestem) Fibrosis | pt_BR |
Subject | Periovular Granulomas | pt_BR |
Subject | Hepatic Fibrosis | pt_BR |
DeCS | Schistosoma mansoni | pt_BR |
DeCS | Fibrose | pt_BR |
DeCS | Granuloma | pt_BR |
DeCS | Cirrose Hepática | pt_BR |