Author | Baro, Barbara | |
Author | Deroost, Katrien | |
Author | Raiol, Tainá | |
Author | Brito, Marcelo | |
Author | Almeida, Anne C. G. | |
Author | Menezes Neto, Armando de | |
Author | Figueiredo, Erick F. G. | |
Author | Alencar, Aline | |
Author | Leitão, Rodrigo | |
Author | Val, Fernando | |
Author | Monteiro, Wuelton Marcelo | |
Author | Oliveira, Anna | |
Author | Armengol, Maria del Pilar | |
Author | Fernández-Becerra, Carmen | |
Author | Lacerda, Marcus V. | |
Author | del Portillo, Hernando A. | |
Access date | 2018-06-22T14:08:25Z | |
Available date | 2018-06-22T14:08:25Z | |
Document date | 2017 | |
Citation | BARO, Barbara et al. Plasmodium vivax gametocytes in the bone marrow of an acute malaria patient and changes in the erythroid miRNA profile. PLoS Negl Trop Dis., v. 11, n. 4, e0005365, 2017 | pt_BR |
ISSN | 1935-2727 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/27055 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Plasmodium | pt_BR |
Subject in Portuguese | sangue | pt_BR |
Title | Plasmodium vivax gametocytes in the bone marrow of an acute malaria patient and changes in the erythroid miRNA profile | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pntd.0005365 | |
Abstract | Plasmodium vivax is the most widely distributed human malaria parasite and responsible for large amounts of disease and burden [1]. The presence of P. vivax in the bone marrow was first noticed in the late 19th century [2], and examinations of sternal bone marrow aspirates were performed as an accessory to examinations of peripheral blood in malaria, including P. vivax [3]. Since then, little progress has been made in studying P. vivax infections in this tissue. One report explored accumulation of dyserythropoietic cells in anaemic infected patients [4]. In addition, two case studies reported P. vivax infections after autologous bone marrow transplantation [5][6], and a third one documented an accidental P. vivax infection due to bone marrow transplantation between a malaria-infected donor and a malaria-free receptor [7]. In Brazil, one patient with persistent thrombocytopaenia and an enlarged spleen was diagnosed with chronic P. vivax malaria after the finding of schizonts in the bone marrow aspirate [8]. In all these reports and case studies, however, parasite loads and life stages found in the bone marrow were not investigated, and no molecular tools were available to rule out mixed infections or to characterize specific parasite stages. | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/ISGlobal. Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic - Universitat de Barcelona. Barcelona, Spain | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação Hospitalar de Hematologia e Hematoterapia do Amazonas. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil | pt_BR |
Affilliation | Institut d’Investigació Germans Trias i Pujol. Badalona, Spain | pt_BR |
Affilliation | Institut d’Investigació Germans Trias i Pujol. Badalona, Spain | pt_BR |
Affilliation | ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB). Hospital Clínic - Universitat de Barcelona, Barcelona. Spain/Institut d’Investigació Germans Trias i Pujol. Badalona, Spain | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil | pt_BR |
Affilliation | ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB). Hospital Clínic - Universitat de Barcelona, Barcelona. Spain/Institut d’Investigació Germans Trias i Pujol. Badalona, Spain | pt_BR |
Subject | Plasmodium | pt_BR |
Subject | Blood | pt_BR |
Subject | Bone marrow | pt_BR |
Subject | Gametocytes | pt_BR |
Subject | Parasitic diseases | pt_BR |
Subject | Bone marrow cells | pt_BR |
Subject | Erythropoiesis | pt_BR |
Subject | MicroRNAs | pt_BR |