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https://www.arca.fiocruz.br/handle/icict/27055
PLASMODIUM VIVAX GAMETOCYTES IN THE BONE MARROW OF AN ACUTE MALARIA PATIENT AND CHANGES IN THE ERYTHROID MIRNA PROFILE
Blood
Bone marrow
Gametocytes
Parasitic diseases
Bone marrow cells
Erythropoiesis
MicroRNAs
Author
Baro, Barbara
Deroost, Katrien
Raiol, Tainá
Brito, Marcelo
Almeida, Anne C. G.
Menezes Neto, Armando de
Figueiredo, Erick F. G.
Alencar, Aline
Leitão, Rodrigo
Val, Fernando
Monteiro, Wuelton Marcelo
Oliveira, Anna
Armengol, Maria del Pilar
Fernández-Becerra, Carmen
Lacerda, Marcus V.
del Portillo, Hernando A.
Deroost, Katrien
Raiol, Tainá
Brito, Marcelo
Almeida, Anne C. G.
Menezes Neto, Armando de
Figueiredo, Erick F. G.
Alencar, Aline
Leitão, Rodrigo
Val, Fernando
Monteiro, Wuelton Marcelo
Oliveira, Anna
Armengol, Maria del Pilar
Fernández-Becerra, Carmen
Lacerda, Marcus V.
del Portillo, Hernando A.
Affilliation
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Manaus, AM, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/ISGlobal. Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic - Universitat de Barcelona. Barcelona, Spain
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Fundação Hospitalar de Hematologia e Hematoterapia do Amazonas. Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil
Institut d’Investigació Germans Trias i Pujol. Badalona, Spain
Institut d’Investigació Germans Trias i Pujol. Badalona, Spain
ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB). Hospital Clínic - Universitat de Barcelona, Barcelona. Spain/Institut d’Investigació Germans Trias i Pujol. Badalona, Spain
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil
ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB). Hospital Clínic - Universitat de Barcelona, Barcelona. Spain/Institut d’Investigació Germans Trias i Pujol. Badalona, Spain
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil/Universidade do Estado do Amazonas. Manaus, AM, Brazil
Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil/ISGlobal. Barcelona Ctr. Int. Health Res. (CRESIB), Hospital Clínic - Universitat de Barcelona. Barcelona, Spain
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil
Fundação Hospitalar de Hematologia e Hematoterapia do Amazonas. Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil
Institut d’Investigació Germans Trias i Pujol. Badalona, Spain
Institut d’Investigació Germans Trias i Pujol. Badalona, Spain
ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB). Hospital Clínic - Universitat de Barcelona, Barcelona. Spain/Institut d’Investigació Germans Trias i Pujol. Badalona, Spain
Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brazil/Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Manaus, AM, Brazil
ISGlobal, Barcelona Ctr. Int. Health Res. (CRESIB). Hospital Clínic - Universitat de Barcelona, Barcelona. Spain/Institut d’Investigació Germans Trias i Pujol. Badalona, Spain
Abstract
Plasmodium vivax is the most widely distributed human malaria parasite and responsible for large amounts of disease and burden [1]. The presence of P. vivax in the bone marrow was first noticed in the late 19th century [2], and examinations of sternal bone marrow aspirates were performed as an accessory to examinations of peripheral blood in malaria, including P. vivax [3]. Since then, little progress has been made in studying P. vivax infections in this tissue. One report explored accumulation of dyserythropoietic cells in anaemic infected patients [4]. In addition, two case studies reported P. vivax infections after autologous bone marrow transplantation [5][6], and a third one documented an accidental P. vivax infection due to bone marrow transplantation between a malaria-infected donor and a malaria-free receptor [7]. In Brazil, one patient with persistent thrombocytopaenia and an enlarged spleen was diagnosed with chronic P. vivax malaria after the finding of schizonts in the bone marrow aspirate [8]. In all these reports and case studies, however, parasite loads and life stages found in the bone marrow were not investigated, and no molecular tools were available to rule out mixed infections or to characterize specific parasite stages.
Keywords
PlasmodiumBlood
Bone marrow
Gametocytes
Parasitic diseases
Bone marrow cells
Erythropoiesis
MicroRNAs
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