Author | Pereira, Denyson Santana | |
Author | Morais, Janaína Pereira | |
Author | Santana, Danielle Gomes | |
Author | Santos, Cliomar Alves | |
Author | Thomazzi, Sara Maria | |
Author | Santos, Charles Estevam dos | |
Author | Antoniolli, Angelo Roberto | |
Author | Bezerra, Daniel Pereira | |
Author | Camargo, Enilton Aparecido | |
Access date | 2017-08-28T13:47:44Z | |
Available date | 2017-08-28T13:47:44Z | |
Document date | 2013 | |
Citation | PEREIRA, D. S. et al. Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats. Journal of Medicinal Plants Research, v. 7, n. 20, p. 1411-1417, 2013. | pt_BR |
ISSN | 1996-0875 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20777 | |
Description | Bezerra, Daniel Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | Fundação de Apoio a Pesquisa e Inovação Tecnológica (FAPITEC/SE; No 019.203.02344/2009-7) and Conselho Nacional de Pesquisa e Desenvolvimento Científico (CNPq; No 562478/2010-8) | pt_BR |
Language | eng | pt_BR |
Publisher | Academic Journals | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Ciclofosfamida | pt_BR |
Subject in Portuguese | inflamação | pt_BR |
Subject in Portuguese | Peroxidação de lipídeos | pt_BR |
Subject in Portuguese | Cistite | pt_BR |
Title | Effects of the ethanol extract of the inner bark of Syderoxylum obtusifolium in the cyclophosphamide-induced cystitis in rats | pt_BR |
Type | Article | pt_BR |
Abstract | In this study, the ethanol extract of the inner bark of the Syderoxylum obtusifolium (EESob) was tested
in the model of cyclophosphamide-induced hemorrhagic cystitis. Male Wistar rats were submitted to
the injection of cyclophosphamide, 1 h after the treatment with EESob (200 or 400 mg/kg) or vehicle.
After 24 h, the urinary bladder was excised and the edema, myeloperoxidase activity and
malondialdehyde formation were measured. Also, myeloperoxidase activity and malondialdehyde
formation in lung, spleen and liver and leukocyte counts in the peripheral blood were evaluated.
Injection of cyclophosphamide increased myeloperoxidase activity and edema. The former was
inhibited by the EESob at 400 mg/kg, but the latter was not affected. Although cyclophosphamide did
not alter the bladder malondialdehyde formation, pre-treatment with EESob at both doses markedly
increased this parameter. Lung and liver parameters or leukocyte counts were not altered by EESob.
The spleen myeloperoxidase activity and malondialdehyde formation were not affected by
cyclophosphamide, but were increased by the treatment with EESob. These results suggests that
EESob administration to rats decrease myeloperoxidase activity in bladder tissue, but is accompanied
by lipoperoxidation in this tissue, as well as in spleen, which do not support the use of EESob to treat
cystitis. | pt_BR |
Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil | pt_BR |
Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil | pt_BR |
Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil | pt_BR |
Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil | pt_BR |
Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil | pt_BR |
Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil | pt_BR |
Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil | pt_BR |
Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil | pt_BR |
Affilliation | Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil | pt_BR |
Subject | Syderoxylum obtusifolium | pt_BR |
Subject | Cyclophosphamide | pt_BR |
Subject | Inflammation | pt_BR |
Subject | Lipid peroxidation | pt_BR |
Subject | Hemorrhagic cystitis | pt_BR |