Author | Santos, Flavia Almeida | |
Author | Silva, Regilane Matos da | |
Author | Tome, Adriana da Rocha | |
Author | Rao, Vietla S. N | |
Author | Pompeu, Margarida Maria de Lima | |
Author | Teixeira, Maria Jania | |
Author | Freitas, Luiz Antonio Rodrigues de | |
Author | Souza, Valderes Lima de | |
Access date | 2017-08-11T17:51:35Z | |
Available date | 2017-08-11T17:51:35Z | |
Document date | 2001 | |
Citation | SANTOS, F. A. et al. 1,8-cineole protects against liver failure in an in-vivo murine model of endotoxemic shock. Journal of Pharmacy and Pharmacology, v. 53, p. 505-511, 2001. | pt_BR |
ISSN | 0022-3573 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20597 | |
Description | Freitas, Luiz Antônio Rodrigues de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, 300870/98-1). | pt_BR |
Language | eng | pt_BR |
Publisher | Wiley | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Insuficiência hepática | pt_BR |
Subject in Portuguese | Choque endotoxico | pt_BR |
Subject in Portuguese | Choque septico | pt_BR |
Subject in Portuguese | Ratos | pt_BR |
Subject in Portuguese | Animais | pt_BR |
Title | 1,8-cineole protects against liver failure in an in-vivo murine model of endotoxemic shock | pt_BR |
Type | Article | pt_BR |
Abstract | The effects of 1,8-cineole on D-galactosamine/lipopolysaccharide (GalN/LPS)-induced shock
model of liver injury was investigated in mice. The co-administration of GalN (700 mg kg−1, i.p.)
and LPS (5 lgkg−1, i.p.) greatly elevated serum concentrations of tumour necrosis factor-a (TNFa),
alanine aminotransferase and aspartate aminotransferase, and induced massive hepatic
necrosis and lethality in 100% of control mice. Pretreatment with 1,8-cineole (400 mg kg−1,
p.o.) and dexamethasone (1 mgkg−1, s.c.), 60 min before GalN/LPS, offered complete protection
(100%) against the lethal shock and acute elevation in serum TNF-a and serum transaminases.
Hepatic necrosis induced by GalN/LPS was also greatly reduced by both 1,8-cineole and
dexamethasone treatment. The results indicate that 1,8-cineole protects mice against GalN/LPSinduced
liver injury through the inhibition of TNF-a production, and suggest that 1,8-cineole
may be a promising agent to combat septic-shock-associated pathologies. | pt_BR |
Affilliation | Federal University of Ceará. Department of Physiology and Pharmacology. Fortaleza, CE, Brasil | pt_BR |
Affilliation | Federal University of Ceará. Department of Physiology and Pharmacology. Fortaleza, CE, Brasil | pt_BR |
Affilliation | Federal University of Ceará. Department of Physiology and Pharmacology. Fortaleza, CE, Brasil | pt_BR |
Affilliation | Federal University of Ceará. Department of Physiology and Pharmacology. Fortaleza, CE, Brasil | pt_BR |
Affilliation | Federal University of Ceará. Department of Pathology and Legal Medicine. Fortaleza, | pt_BR |
Affilliation | Federal University of Ceará. Department of Pathology and Legal Medicine. Fortaleza, | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Laboratório de Patologia e Biologia Celular. Rio de Janeiro, RJ, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Laboratório de Patologia e Biologia Celular. Rio de Janeiro, RJ, Brasil | pt_BR |
Subject | Hepatic failure | pt_BR |
Subject | Endotoxemic shock | pt_BR |
Subject | Septic shock | pt_BR |
Subject | Mice | pt_BR |
Subject | Animals | pt_BR |