Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/20597
Title: 1,8-cineole protects against liver failure in an in-vivo murine model of endotoxemic shock
Authors: Santos, Flavia Almeida
Silva, Regilane Matos da
Tome, Adriana da Rocha
Rao, Vietla S. N
Pompeu, Margarida Maria de Lima
Teixeira, Maria Jania
Freitas, Luiz Antonio Rodrigues de
Souza, Valderes Lima de
Affilliation: Federal University of Ceará. Department of Physiology and Pharmacology. Fortaleza, CE, Brasil
Federal University of Ceará. Department of Physiology and Pharmacology. Fortaleza, CE, Brasil
Federal University of Ceará. Department of Physiology and Pharmacology. Fortaleza, CE, Brasil
Federal University of Ceará. Department of Physiology and Pharmacology. Fortaleza, CE, Brasil
Federal University of Ceará. Department of Pathology and Legal Medicine. Fortaleza,
Federal University of Ceará. Department of Pathology and Legal Medicine. Fortaleza,
Fundação Oswaldo Cruz. Laboratório de Patologia e Biologia Celular. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Laboratório de Patologia e Biologia Celular. Rio de Janeiro, RJ, Brasil
Abstract: The effects of 1,8-cineole on D-galactosamine/lipopolysaccharide (GalN/LPS)-induced shock model of liver injury was investigated in mice. The co-administration of GalN (700 mg kg−1, i.p.) and LPS (5 lgkg−1, i.p.) greatly elevated serum concentrations of tumour necrosis factor-a (TNFa), alanine aminotransferase and aspartate aminotransferase, and induced massive hepatic necrosis and lethality in 100% of control mice. Pretreatment with 1,8-cineole (400 mg kg−1, p.o.) and dexamethasone (1 mgkg−1, s.c.), 60 min before GalN/LPS, offered complete protection (100%) against the lethal shock and acute elevation in serum TNF-a and serum transaminases. Hepatic necrosis induced by GalN/LPS was also greatly reduced by both 1,8-cineole and dexamethasone treatment. The results indicate that 1,8-cineole protects mice against GalN/LPSinduced liver injury through the inhibition of TNF-a production, and suggest that 1,8-cineole may be a promising agent to combat septic-shock-associated pathologies.
Keywords: Hepatic failure
Endotoxemic shock
Septic shock
Mice
Animals
keywords: Insuficiência hepática
Choque endotoxico
Choque septico
Ratos
Animais
Issue Date: 2001
Publisher: Wiley
Citation: SANTOS, F. A. et al. 1,8-cineole protects against liver failure in an in-vivo murine model of endotoxemic shock. Journal of Pharmacy and Pharmacology, v. 53, p. 505-511, 2001.
Description: Freitas, Luiz Antônio Rodrigues de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
ISSN: 0022-3573
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
Santos FA 1,8-cineole protects....pdf305.82 kBAdobe PDFView/Open


FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.