Author | Dias, Rosane Borges | |
Author | Valverde, Ludmila de Faro | |
Author | Sales, Caroline Brandi Schlaepfer | |
Author | Guimarães, Vanessa Sousa Nazaré | |
Author | Cabral, Márcia Grillo | |
Author | Xavier, Flávia Caló de Aquino | |
Author | Santos, Jean Nunes dos | |
Author | Ramos, Eduardo Antônio Gonçalves | |
Author | Rocha, Clarissa Araújo Gurgel | |
Access date | 2017-03-17T16:54:02Z | |
Available date | 2017-03-17T16:54:02Z | |
Document date | 2016 | |
Citation | DIAS, R. B. et al. Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia. Applied Immunohistochemistry & Molecular Morphology, v. 24, p. 595–602, 2016. | pt_BR |
ISSN | 1541-2016 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/18073 | |
Sponsorship | National Council for Scientific and Technological Development (CNPq, Brazil). Foundation to Support Research in
the State of Bahia (FAPESB, Bahia, Brazil) | pt_BR |
Language | eng | pt_BR |
Publisher | Lippincott, Williams & Wilkins | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Displasia epitelial oral | pt_BR |
Subject in Portuguese | Proteínas Hedgehog | pt_BR |
Subject in Portuguese | Lesão pré-maligna | pt_BR |
Title | Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia | pt_BR |
Type | Article | pt_BR |
DOI | 10.1097/PAI.0000000000000225 | |
Abstract | The aim of this study was to characterize the profile of the proteins involved in the Hedgehog signaling pathway to aid in the understanding of the pathogenesis of oral epithelial dysplasia (OED). The proteins SHH, PTCH1, HHIP, SUFU, GLI1, and cyclin D1 were evaluated by immunohistochemistry in 25 cases of OED, 4 of non-neoplasic oral mucosa, 8 of inflammatory fibrous hyperplasia and 5 of hyperkeratosis. SHH proteins were predominant in OED cases. Although PTCH1 protein was observed in all cases, this molecule was more highly expressed in OED. The inhibitor protein SUFU was present in OED and HHIP protein was overexpressed in OED. GLI1 proteins were predominantly found in the nuclei of epithelial cells in OED. Basal and suprabasal cells in the epithelial lining were positive for cyclin D1 only in OED. In conclusion, comparative analysis of the proteins involved in the Hedgehog pathway suggests that enhanced expression of these proteins can play an important role in the biological behavior of OED. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Rio de Janeiro. School of Dentistry. Department of Pathology and Oral Diagnosis. Rio de Janeiro, RJ, Brazil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil | pt_BR |
Affilliation | Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil | pt_BR |
Subject | Oral epithelial dysplasia | pt_BR |
Subject | Hedgehog proteins | pt_BR |
Subject | Premalignant lesion | pt_BR |