Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/18073
Title: Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia
Authors: Dias, Rosane Borges
Valverde, Ludmila de Faro
Sales, Caroline Brandi Schlaepfer
Guimarães, Vanessa Sousa Nazaré
Cabral, Márcia Grillo
Xavier, Flávia Caló de Aquino
Santos, Jean Nunes dos
Ramos, Eduardo Antônio Gonçalves
Rocha, Clarissa Araújo Gurgel
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Federal University of Rio de Janeiro. School of Dentistry. Department of Pathology and Oral Diagnosis. Rio de Janeiro, RJ, Brazil
Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Federal University of Bahia. School of Dentistry. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil
Abstract: The aim of this study was to characterize the profile of the proteins involved in the Hedgehog signaling pathway to aid in the understanding of the pathogenesis of oral epithelial dysplasia (OED). The proteins SHH, PTCH1, HHIP, SUFU, GLI1, and cyclin D1 were evaluated by immunohistochemistry in 25 cases of OED, 4 of non-neoplasic oral mucosa, 8 of inflammatory fibrous hyperplasia and 5 of hyperkeratosis. SHH proteins were predominant in OED cases. Although PTCH1 protein was observed in all cases, this molecule was more highly expressed in OED. The inhibitor protein SUFU was present in OED and HHIP protein was overexpressed in OED. GLI1 proteins were predominantly found in the nuclei of epithelial cells in OED. Basal and suprabasal cells in the epithelial lining were positive for cyclin D1 only in OED. In conclusion, comparative analysis of the proteins involved in the Hedgehog pathway suggests that enhanced expression of these proteins can play an important role in the biological behavior of OED.
Keywords: Oral epithelial dysplasia
Hedgehog proteins
Premalignant lesion
keywords: Displasia epitelial oral
Proteínas Hedgehog
Lesão pré-maligna
Issue Date: 2016
Publisher: Lippincott, Williams & Wilkins
Citation: DIAS, R. B. et al. Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia. Applied Immunohistochemistry & Molecular Morphology, v. 24, p. 595–602, 2016.
DOI: 10.1097/PAI.0000000000000225
ISSN: 1541-2016
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

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