Author | Muniz, Aline de Couto | |
Author | Bacellar, Olívia | |
Author | Lago, Ednaldo Lima | |
Author | Carvalho, Augusto M | |
Author | Carneiro, Pedro Paulo | |
Author | Guimarães, Luiz Henrique | |
Author | Rocha, Paulo N | |
Author | Carvalho, Lucas P | |
Author | Glesby, Marshall | |
Author | Carvalho Filho, Edgar Marcelino | |
Access date | 2016-12-01T16:45:05Z | |
Available date | 2016-12-01T16:45:05Z | |
Document date | 2016 | |
Citation | MUNIZ, A. C. et al. Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study. Journal of Infectious Diseases,v. 214, p. 570–576, 2016. | pt_BR |
ISSN | 0022-1899 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/16408 | |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmaniose | pt_BR |
Subject in Portuguese | Contatos domésticos | pt_BR |
Subject in Portuguese | Leishmania braziliensis | pt_BR |
Subject in Portuguese | Leishmaniose cutânea | pt_BR |
Subject in Portuguese | IFN-y | pt_BR |
Subject in Portuguese | Leishmania teste cutâneo | pt_BR |
Title | Immunologic Markers of Protection in Leishmania (Viannia) braziliensis Infection: A 5-Year Cohort Study | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/infdis/jiw196 | |
Abstract | The control of Leishmania braziliensis by individuals with subclinical infection (SC) are unknown.Methods. A cohort of 308 household contacts (HCs) of patients with cutaneous leishmaniasis (CL) was established in 2010 in an
endemic area and followed up for 5 years. Whole-blood cultures stimulated with soluble Leishmania antigen and a Leishmania skin
test (LST) were performed in years 0, 2, and 4. The identification of the lymphocyte subsets secreting interferon (IFN) γ and the
ability of monocytes to control Leishmania were determined.
Results. During follow-up, 118 subjects (38.3%) had evidence of L. braziliensis infection. Of the HCs, CL was documented in 45
(14.6%), 101 (32.8%) had SC infection, and 162 (52.6%) did not have evidence of exposure to L. braziliensis. The ratio of infection to
disease was 3.2:1. IFN-γ production, mainly by natural killer cells, was associated with protection, and a positive LST result did not
prevent development of disease. Moreover, monocytes from subjects with SC infection were less permissive to parasite penetration
and had a greater ability to control L. braziliensis than cells from patients with CL.
Conclusions. Protection against CL was associated with IFN-γ production, negative LST results, impaired ability of Leishmania
to penetrate monocytes, and increased ability to control Leishmania growth | pt_BR |
Affilliation | Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Federal University of Bahia School of Medicine. Department of Medicine and Diagnostic Support. Salvador, BA, Brasil | pt_BR |
Affilliation | Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Weill Cornell Medical College. New York, New York | pt_BR |
Affilliation | Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Subject | Subclinical leishmaniasis | pt_BR |
Subject | Household contacts | pt_BR |
Subject | Leishmania braziliensis | pt_BR |
Subject | Cutaneous leishmaniasis | pt_BR |
Subject | IFN-γ | pt_BR |
Subject | Leishmania skin test | pt_BR |