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IMMUNOLOGIC MARKERS OF PROTECTION IN LEISHMANIA (VIANNIA) BRAZILIENSIS INFECTION: A 5-YEAR COHORT STUDY
Contatos domésticos
Leishmania braziliensis
Leishmaniose cutânea
IFN-y
Leishmania teste cutâneo
Household contacts
Leishmania braziliensis
Cutaneous leishmaniasis
IFN-γ
Leishmania skin test
Author
Affilliation
Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil
Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil
Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil
Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Federal University of Bahia School of Medicine. Department of Medicine and Diagnostic Support. Salvador, BA, Brasil
Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Weill Cornell Medical College. New York, New York
Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil
Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Federal University of Bahia School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil
Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil
Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Federal University of Bahia School of Medicine. Department of Medicine and Diagnostic Support. Salvador, BA, Brasil
Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Weill Cornell Medical College. New York, New York
Federal University of Bahia. Hospital Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Federal University of Bahia. School of Medicine. Postgraduate Program in Health Sciences. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract
The control of Leishmania braziliensis by individuals with subclinical infection (SC) are unknown.Methods. A cohort of 308 household contacts (HCs) of patients with cutaneous leishmaniasis (CL) was established in 2010 in an
endemic area and followed up for 5 years. Whole-blood cultures stimulated with soluble Leishmania antigen and a Leishmania skin
test (LST) were performed in years 0, 2, and 4. The identification of the lymphocyte subsets secreting interferon (IFN) γ and the
ability of monocytes to control Leishmania were determined.
Results. During follow-up, 118 subjects (38.3%) had evidence of L. braziliensis infection. Of the HCs, CL was documented in 45
(14.6%), 101 (32.8%) had SC infection, and 162 (52.6%) did not have evidence of exposure to L. braziliensis. The ratio of infection to
disease was 3.2:1. IFN-γ production, mainly by natural killer cells, was associated with protection, and a positive LST result did not
prevent development of disease. Moreover, monocytes from subjects with SC infection were less permissive to parasite penetration
and had a greater ability to control L. braziliensis than cells from patients with CL.
Conclusions. Protection against CL was associated with IFN-γ production, negative LST results, impaired ability of Leishmania
to penetrate monocytes, and increased ability to control Leishmania growth
Keywords in Portuguese
LeishmanioseContatos domésticos
Leishmania braziliensis
Leishmaniose cutânea
IFN-y
Leishmania teste cutâneo
Keywords
Subclinical leishmaniasisHousehold contacts
Leishmania braziliensis
Cutaneous leishmaniasis
IFN-γ
Leishmania skin test
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