Author | Vieira, Maria das Graças Silva | |
Author | Oliveira, Luis Fabiano Borges | |
Author | Arruda, Sérgio Marcos | |
Author | Bittencourt, Achilea Candida Lisboa | |
Author | Barbosa Junior, Aryon de Almeida | |
Author | Barral Netto, Manoel | |
Author | Barral, Aldina Maria Prado | |
Access date | 2016-02-29T13:21:40Z | |
Available date | 2016-02-29T13:21:40Z | |
Document date | 2002 | |
Citation | VIEIRA, M. G. S. et al. B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases. Memórias do Instituto Oswaldo Cruz, v. 97, n. 7, p. 979-983, 2002. | pt_BR |
ISSN | 0074-0276 | |
URI | https://www.arca.fiocruz.br/handle/icict/12892 | |
Language | eng | pt_BR |
Publisher | Instituto Oswaldo Cruz | pt_BR |
Rights | open access | pt_BR |
Title | B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases | pt_BR |
Type | Article | pt_BR |
Abstract | Biopsies from human localized cutaneous lesions (LCL n = 7) or disseminated lesions (DL n = 8) cases were
characterized according to cellular infiltration, frequency of cytokine (IFN-g, TNF-a) or iNOS enzyme producing
cells. LCL, the most usual form of the disease with usually one or two lesions, exhibits extensive tissue damage. DL
is a rare form with widespread lesions throughout the body; exhibiting poor parasite containment but less tissue
damage. We demonstrated that LCL lesions exhibit higher frequency of B lymphocytes and a higher intensity of IFN-
g expression. In both forms of the disease CD8+ were found in higher frequency than CD4+ T cells. Frequency of
TNF-a and iNOS producing cells, as well as the frequency of CD68+ macrophages, did not differ between LCL and
DL. Our findings reinforce the link between an efficient control of parasite and tissue damage, implicating higher
frequency of IFN-g producing cells, as well as its possible counteraction by infiltrated B cells and hence possible
humoral immune response in situ. | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital Professor Edgard Santos. Serviço de Anatomia Patológica. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital Professor Edgard Santos. Serviço de Anatomia Patológica. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / ***Instituto de Investigação em Imunologia, Instituto do Milênio, São Paulo, SP, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / ***Instituto de Investigação em Imunologia, Instituto do Milênio, São Paulo, SP, Brasil | pt_BR |
Subject | Leishmaniasis | pt_BR |
Subject | B lymphocytes | pt_BR |
Subject | Cytokines | pt_BR |
Subject | CD8+ T cells | pt_BR |
Subject | IFN-g | pt_BR |