Please use this identifier to cite or link to this item: http://www.arca.fiocruz.br/handle/icict/12892
Title: B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases
Authors: Vieira, Maria das Graças Silva
Oliveira, Luis Fabiano Borges
Arruda, Sérgio Marcos
Bittencourt, Achilea Candida Lisboa
Barbosa Junior, Aryon de Almeida
Barral Netto, Manoel
Barral, Aldina Maria Prado
Affilliation: Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital Professor Edgard Santos. Serviço de Anatomia Patológica. Salvador, BA, Brasil
Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital Professor Edgard Santos. Serviço de Anatomia Patológica. Salvador, BA, Brasil
Fundação Oswaldo Cruz, Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / ***Instituto de Investigação em Imunologia, Instituto do Milênio, São Paulo, SP, Brasil
Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / ***Instituto de Investigação em Imunologia, Instituto do Milênio, São Paulo, SP, Brasil
Abstract: Biopsies from human localized cutaneous lesions (LCL n = 7) or disseminated lesions (DL n = 8) cases were characterized according to cellular infiltration, frequency of cytokine (IFN-g, TNF-a) or iNOS enzyme producing cells. LCL, the most usual form of the disease with usually one or two lesions, exhibits extensive tissue damage. DL is a rare form with widespread lesions throughout the body; exhibiting poor parasite containment but less tissue damage. We demonstrated that LCL lesions exhibit higher frequency of B lymphocytes and a higher intensity of IFN- g expression. In both forms of the disease CD8+ were found in higher frequency than CD4+ T cells. Frequency of TNF-a and iNOS producing cells, as well as the frequency of CD68+ macrophages, did not differ between LCL and DL. Our findings reinforce the link between an efficient control of parasite and tissue damage, implicating higher frequency of IFN-g producing cells, as well as its possible counteraction by infiltrated B cells and hence possible humoral immune response in situ.
Keywords: Leishmaniasis
B lymphocytes
Cytokines
CD8+ T cells
IFN-g
Issue Date: 2002
Publisher: Instituto Oswaldo Cruz
Citation: VIEIRA, M. G. S. et al. B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases. Memórias do Instituto Oswaldo Cruz, v. 97, n. 7, p. 979-983, 2002.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

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