Author | Xavier, Marcelo Antônio Pascoal | |
Author | Figueiredo, Anna Carolina Cançado | |
Author | Gomes, Luciana Inácia | |
Author | Pascoal, Vanessa Peruhype Magalhães | |
Author | Silva, Carlos Eduardo Calzavara | |
Author | Costa, Marcelo Azevedo | |
Author | Reis, Ilka Afonso | |
Author | Bonjardim, Claudio Antônio | |
Author | Kroon, Erna Geessien | |
Author | Oliveira, Jaquelline Germano de | |
Author | Ferreira, Paulo César Peregrino | |
Access date | 2016-01-26T15:04:58Z | |
Available date | 2016-01-26T15:04:58Z | |
Document date | 2015 | |
Citation | XAVIER, Marcelo Antonio Pascoal et al. RAP1 GTPase Overexpression is Associated with Cervical Intraepithelial Neoplasia. PLoS One, vol. 10, n. 4, p. e0123531, 2015. | pt_BR |
ISSN | 1932-6203 | |
URI | https://www.arca.fiocruz.br/handle/icict/12624 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Title | RAP1 GTPase Overexpression is Associated with Cervical Intraepithelial Neoplasia. | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0123531. eCollection 2015. | |
Abstract | RAP1 (RAS proximate 1), a small GTP-binding protein of the RAS superfamily, is a putative oncogene that is highly expressed in several malignant cell lines and types of cancers, including some types of squamous cell carcinoma. However, the participation of RAP1 in cervical carcinogenesis is unknown. We conducted a cross-sectional study of paraffin-embedded cervical biopsies to determine the association of RAP1 with cervical intraepithelial neoplasia (CIN). Standard and quantitative immunohistochemistry assessment of RAP1 expression in fixed tissue was performed on 183 paraffin-embedded cervical biopsies that were classified as normal or non-dysplastic mucosa (NDM) (n = 33); CIN grade 1 (n = 84) and CIN grade 2/3 (n = 66). A gradual increase in RAP1 expression in NDM < CIN 1 < CIN 2/3 (p<0.001) specimens was observed and was in agreement with the histopathologic diagnosis. A progressive increase in the RAP1 expression levels increased the risk of CIN 1 [odds ratio (OR) = 3.50; 95% confidence interval (CI) 1.30-10.64] 3.5 fold and the risk of CIN 2/3 (OR = 19.86, 95% CI 6.40-70.79) nearly 20 fold when compared to NDM. In addition, stereotype ordinal regression analysis showed that this progressive increase in RAP1 expression more strongly impacted CIN 2/3 than CIN 1. Our findings suggest that RAP1 may be a useful biomarker for the diagnosis of CIN | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Escola de Engenharia. Departamento de Engenharia de Produção. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Estatística. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte MG, Brasil | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brasil | pt_BR |
Subject | Cell staining | pt_BR |
Subject | Immunostaining | pt_BR |
Subject | Biomarkers | pt_BR |
Subject | Nuclear staining | pt_BR |
Subject | Epithelium | pt_BR |
Subject | Morphometry | pt_BR |
Subject | Biopsy | pt_BR |
Subject | Carcinogenesis | pt_BR |