Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease.

College of Veterinary Medicine & Biomedical Sciences. Colorado State University. Departments of Pathology and Environmental Health. Fort Collins, CO, USA
College of Veterinary Medicine & Biomedical Sciences. Colorado State University. Departments of Pathology and Environmental Health. Fort Collins, CO, USA
College of Veterinary Medicine & Biomedical Sciences. Colorado State University. Departments of Pathology and Environmental Health. Fort Collins, CO, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil

Resumen en ingles

Since interleukin-6 (IL-6) may promote Th2 responses, we infected BALB IL-6-deficient (IL-6(-/-)) mice with Leishmania major. There was not a significant difference between the courses of infection (lesion size and parasite burden) in IL-6(-/-) and wild-type mice, but IL-6(-/-) mice expressed lower levels of Th2- and Th1-associated cytokines.

DeCS

Citocinas/genética
Regulação da Expressão Gênica
Interleucina-6/imunologia
Leishmania major/imunologia
Leishmaniose Cutânea/imunologia
Animais
Suscetibilidade a Doenças/imunologia
Regulação para Baixo
Interleucina-6/genética
Leishmaniose Cutânea/genética
Leishmaniose Cutânea/fisiopatologia
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Knockout
Células Th1/imunologia

Editor

American Society for Microbiology

Referencia

TITUS, R. G. et al. Interleukin-6 deficiency influences cytokine expression in susceptible BALB mice infected with Leishmania major but does not alter the outcome of disease. Infection and Immunity, v. 69, n. 8, p. 5189-5192, 2001.

DOI

10.1128/IAI.69.8.5189–5192.2001

ISSN

0104-5695

Por favor, use este identificador para citar o enlazar este ítem: https://www.arca.fiocruz.br/handle/icict/9911

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