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CELL THERAPY IN CHAGAS DISEASE
Trypanosoma cruzi
Cardiomiopatia
America Latina
Miocardiopatia chagásica
Cirurgia
Transplante de células
Transplante da medula óssea
Animais
Author
Affilliation
Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Albert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NY, USA / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil
Albert Einstein College of Medicine. Department of Physiology & Biophysics. Bronx, NY, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Albert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NY, USA
Albert Einstein College of Medicine. Department of Pathology. Bronx, NY, USA
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil
Albert Einstein College of Medicine. Department of Physiology & Biophysics. Bronx, NY, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Albert Einstein College of Medicine. Dominick P. Purpura. Department of Neuroscience. Bronx, NY, USA
Albert Einstein College of Medicine. Department of Pathology. Bronx, NY, USA
Abstract
Chagas disease which is caused by the parasite Trypanosoma cruzi is an important cause of cardiomyopathy in Latin America. In
later stages chagasic cardiomyopathy is associated with congestive heart failure which is often refractory to medical therapy. In
these individuals heart transplantation has been attempted. However, this procedure is fraught with many problems attributable
to the surgery and the postsurgical administration of immunosuppressive drugs. Studies inmice suggest that the transplantation of
bone-marrow-derived cells ameliorates the inflammation and fibrosis in the heart associated with this infection. Cardiac magnetic
resonance imaging reveals that bone marrow transplantation ameliorates the infection induced right ventricular enlargement. On
the basis of these animal studies the safety of autologous bone marrow transplantation has been assessed in patients with chagasic
end-stage heart disease. The initial results are encouraging and more studies need to be performed.
Keywords in Portuguese
Doença de chagasTrypanosoma cruzi
Cardiomiopatia
America Latina
Miocardiopatia chagásica
Cirurgia
Transplante de células
Transplante da medula óssea
Animais
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