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DENSITY OF MAST CELLS AND MICROVESSELS IN MINOR SALIVARY GLAND TUMORS
Microvasos/patologia
Neoplasias das Glândulas Salivares/irrigação sanguínea
Neoplasias das Glândulas Salivares/patologia
Glândulas Salivares Menores
Adenocarcinoma/irrigação sanguínea
Adenocarcinoma/patologia
Adenoma Pleomorfo/irrigação sanguínea
Adenoma Pleomorfo/patologia
Carcinoma Adenoide Cístico/irrigação sanguínea
Carcinoma Adenoide Cístico/patologia
Carcinoma Mucoepidermoide/irrigação sanguínea
Humanos
Triptases/análise
Marcadores Biológicos de Tumor
Fator de von Willebrand/análise
Author
Affilliation
Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil.
Aristides Maltez Hospital. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology. Salvador, BA, Brasil.
Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil.
Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil.
Federal University of Bahia. Department of Bio-morphology. Institute of Health Sciences. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Aristides Maltez Hospital. Department of Head and Neck Surgery. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil.
State University of Feira de Santana. Department of Health (Oral Pathology). Feira de Santana, BA, Brasil.
Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil.
Aristides Maltez Hospital. Salvador, BA, Brasil / Federal University of Bahia. Department of Pathology. Salvador, BA, Brasil.
Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil.
Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil.
Federal University of Bahia. Department of Bio-morphology. Institute of Health Sciences. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Aristides Maltez Hospital. Department of Head and Neck Surgery. Salvador, BA, Brasil
Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil.
State University of Feira de Santana. Department of Health (Oral Pathology). Feira de Santana, BA, Brasil.
Federal University of Bahia. School of Dentistry. Laboratory of Surgical Pathology. Department of Oral Pathology. Salvador, BA, Brasil.
Abstract
The aim of this study was to investigate the density of mast cells and microvessels in minor salivary gland tumors. Forty-one cases of minor salivary gland tumors (pleomorphic adenoma, n = 10; adenoid cystic carcinoma, n = 11; mucoepidermoid carcinoma, n = 10; and polymorphous low-grade adenocarcinoma) were investigated using immunohistochemistry for mast cell tryptase and von-Willebrand factor. Density of mast cells was higher in mucoepidermoid carcinoma; however, no differences in the number of these cells were observed between the different types of tumors (p > 0.05). The number of mast cells was higher in periparenchymal areas in all tumors, but the difference was not significant (p > 0.05). Mucoepidermoid carcinoma showed the largest number of periparenchymal mast cells, whereas pleomorphic adenomas showed the smallest number of intraparenchymal mast cells (p > 0.05). The highest microvessel density was observed in mucoepidermoid carcinomas, being this difference statistically significant when mucoepidermoid carcinoma was compared to pleomorphic adenoma (p = 0.0034) and polymorphous low-grade adenocarcinoma (p = 0.004). Microvessel density was significantly higher in adenoid cystic carcinoma when compared to pleomorphic adenoma (p = 0.0406) and polymorphous low-grade adenocarcinoma (p = 0.0123). Comparison of mast cells and microvessel densities showed no significant difference between tumors. A quantitative difference in mast cells and microvessels was observed, particularly in mucoepidermoid carcinoma, a finding supporting the aggressive behavior of malignant salivary gland tumors without myoepithelial differentiation. Further studies are needed to determine the role of mast cells in angiogenesis, as well as in the development and biological behavior of these tumors.
DeCS
MastócitosMicrovasos/patologia
Neoplasias das Glândulas Salivares/irrigação sanguínea
Neoplasias das Glândulas Salivares/patologia
Glândulas Salivares Menores
Adenocarcinoma/irrigação sanguínea
Adenocarcinoma/patologia
Adenoma Pleomorfo/irrigação sanguínea
Adenoma Pleomorfo/patologia
Carcinoma Adenoide Cístico/irrigação sanguínea
Carcinoma Adenoide Cístico/patologia
Carcinoma Mucoepidermoide/irrigação sanguínea
Humanos
Triptases/análise
Marcadores Biológicos de Tumor
Fator de von Willebrand/análise
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